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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1999-8-5
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pubmed:abstractText |
The Fas ligand is predominantly expressed in activated T lymphocytes and is one of the major effector molecules of cytotoxic T lymphocytes and natural killer cells. Previously, we found excessive apoptosis of epithelial cells and infiltrating lymphocytes expressing Fas ligand mRNA in the lung tissue of bleomycin-induced pulmonary fibrosis in mice. Here we demonstrated that the administration of a soluble form of Fas antigen or anti-Fas ligand antibody prevented the development of this model and that lpr and gld mice were resistant against the induction of pneumopathy. These results suggest that the Fas-Fas ligand pathway plays an essential role in the development of pulmonary fibrosis and that preventing this pathway could have therapeutic value in lung injury and fibrosis.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393694-10393691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393694-1372394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393694-13786180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393694-1713127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393694-2475758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393694-6361560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393694-6693832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393694-7505205,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393694-7509364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393694-7511063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393694-7514559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393694-7518614,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393694-7520535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393694-7530335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393694-7530336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393694-7530337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393694-7533498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393694-7594569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393694-7689176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393694-7693342,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393694-7693500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393694-7706720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393694-7826947,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393694-8326006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393694-8627178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393694-8676085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393694-8701992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393694-8756825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393694-8780388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393694-8998084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393694-9018234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393694-9308912,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393694-9317104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393694-9809553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393694-9870917
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD95,
http://linkedlifedata.com/resource/pubmed/chemical/Bleomycin,
http://linkedlifedata.com/resource/pubmed/chemical/FASLG protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Fas Ligand Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Fasl protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxyproline,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin Fc Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0021-9738
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pubmed:author |
pubmed-author:HagimotoNN,
pubmed-author:HareJJ,
pubmed-author:KawasakiMM,
pubmed-author:KunitakeRR,
pubmed-author:KuwanoKK,
pubmed-author:MaeyamaTT,
pubmed-author:MiyazakiHH,
pubmed-author:NagataSS,
pubmed-author:NakamuraNN,
pubmed-author:SudaTT,
pubmed-author:YatomiTT
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pubmed:issnType |
Print
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pubmed:volume |
104
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
13-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10393694-Animals,
pubmed-meshheading:10393694-Antigens, CD95,
pubmed-meshheading:10393694-Apoptosis,
pubmed-meshheading:10393694-Bleomycin,
pubmed-meshheading:10393694-Fas Ligand Protein,
pubmed-meshheading:10393694-Humans,
pubmed-meshheading:10393694-Hydroxyproline,
pubmed-meshheading:10393694-Immunoglobulin Fc Fragments,
pubmed-meshheading:10393694-In Situ Nick-End Labeling,
pubmed-meshheading:10393694-Killer Cells, Natural,
pubmed-meshheading:10393694-Lung,
pubmed-meshheading:10393694-Membrane Glycoproteins,
pubmed-meshheading:10393694-Mice,
pubmed-meshheading:10393694-Mice, Inbred C3H,
pubmed-meshheading:10393694-Mice, Inbred ICR,
pubmed-meshheading:10393694-Mice, Inbred MRL lpr,
pubmed-meshheading:10393694-Mice, Mutant Strains,
pubmed-meshheading:10393694-Phagocytosis,
pubmed-meshheading:10393694-Pulmonary Fibrosis,
pubmed-meshheading:10393694-Recombinant Fusion Proteins,
pubmed-meshheading:10393694-T-Lymphocytes, Cytotoxic
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pubmed:year |
1999
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