| pubmed-article:10390024 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10390024 | lifeskim:mentions | umls-concept:C0228174 | lld:lifeskim |
| pubmed-article:10390024 | lifeskim:mentions | umls-concept:C0014556 | lld:lifeskim |
| pubmed-article:10390024 | lifeskim:mentions | umls-concept:C0311400 | lld:lifeskim |
| pubmed-article:10390024 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:10390024 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:10390024 | pubmed:dateCreated | 1999-9-23 | lld:pubmed |
| pubmed-article:10390024 | pubmed:abstractText | Patients with left temporal lobe epilepsy demonstrate language impairments that are not well understood. To explore abnormal patterns of brain functional connections with respect to language processing, we applied a principal component analysis to resting regional cerebral metabolic data obtained with positron emission tomography in patients with right- and left-sided temporal lobe epilepsy and controls. Two principal components were expressed differentially among the groups. One principal component comprised a pattern of metabolic interactions involving left inferior frontal and left superior temporal regions-corresponding to Broca's and Wernicke's areas, respectively-and right mesial temporal cortex and right thalamus. Functional couplings between these brain regions were abnormally enhanced in the left-sided epilepsy patients. The right thalamic left superior temporal coupling was also abnormally enhanced in the right-sided epilepsy patients, but differentially from that in the left-sided patients. The other principal component was characterized by a pattern of metabolic interactions involving right and left mid prefrontal and right superior temporal cortex. Although both the right- and left-sided epilepsy patients showed decreased functional couplings between left mid prefrontal and the other brain regions, a weaker right-left mid prefrontal coupling in the left-sided epilepsy patients best distinguished them from the right-sided patients. The two mutually independent, abnormal metabolic patterns each predicted verbal intelligence deficits in the patients. The findings suggest a site-dependent reorganization of two independent, language-subserving pathways in temporal lobe epilepsy. | lld:pubmed |
| pubmed-article:10390024 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10390024 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10390024 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10390024 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10390024 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10390024 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10390024 | pubmed:issn | 0028-3932 | lld:pubmed |
| pubmed-article:10390024 | pubmed:author | pubmed-author:ArnoldSS | lld:pubmed |
| pubmed-article:10390024 | pubmed:author | pubmed-author:NiemannHH | lld:pubmed |
| pubmed-article:10390024 | pubmed:author | pubmed-author:PettigrewK... | lld:pubmed |
| pubmed-article:10390024 | pubmed:author | pubmed-author:AzariN PNP | lld:pubmed |
| pubmed-article:10390024 | pubmed:author | pubmed-author:SeitzR JRJ | lld:pubmed |
| pubmed-article:10390024 | pubmed:author | pubmed-author:KnorrUU | lld:pubmed |
| pubmed-article:10390024 | pubmed:author | pubmed-author:EbnerAA | lld:pubmed |
| pubmed-article:10390024 | pubmed:author | pubmed-author:WitteO WOW | lld:pubmed |
| pubmed-article:10390024 | pubmed:author | pubmed-author:AntkeCC | lld:pubmed |
| pubmed-article:10390024 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10390024 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:10390024 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10390024 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10390024 | pubmed:pagination | 625-36 | lld:pubmed |
| pubmed-article:10390024 | pubmed:dateRevised | 2009-11-11 | lld:pubmed |
| pubmed-article:10390024 | pubmed:meshHeading | pubmed-meshheading:10390024... | lld:pubmed |
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| pubmed-article:10390024 | pubmed:meshHeading | pubmed-meshheading:10390024... | lld:pubmed |
| pubmed-article:10390024 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10390024 | pubmed:articleTitle | Reorganized cerebral metabolic interactions in temporal lobe epilepsy. | lld:pubmed |
| pubmed-article:10390024 | pubmed:affiliation | Department of Neurology, Heinrich-Heine-University, Duesseldorf, Germany. | lld:pubmed |
| pubmed-article:10390024 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10390024 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10390024 | lld:pubmed |
