Source:http://linkedlifedata.com/resource/pubmed/id/10390024
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1999-9-23
|
| pubmed:abstractText |
Patients with left temporal lobe epilepsy demonstrate language impairments that are not well understood. To explore abnormal patterns of brain functional connections with respect to language processing, we applied a principal component analysis to resting regional cerebral metabolic data obtained with positron emission tomography in patients with right- and left-sided temporal lobe epilepsy and controls. Two principal components were expressed differentially among the groups. One principal component comprised a pattern of metabolic interactions involving left inferior frontal and left superior temporal regions-corresponding to Broca's and Wernicke's areas, respectively-and right mesial temporal cortex and right thalamus. Functional couplings between these brain regions were abnormally enhanced in the left-sided epilepsy patients. The right thalamic left superior temporal coupling was also abnormally enhanced in the right-sided epilepsy patients, but differentially from that in the left-sided patients. The other principal component was characterized by a pattern of metabolic interactions involving right and left mid prefrontal and right superior temporal cortex. Although both the right- and left-sided epilepsy patients showed decreased functional couplings between left mid prefrontal and the other brain regions, a weaker right-left mid prefrontal coupling in the left-sided epilepsy patients best distinguished them from the right-sided patients. The two mutually independent, abnormal metabolic patterns each predicted verbal intelligence deficits in the patients. The findings suggest a site-dependent reorganization of two independent, language-subserving pathways in temporal lobe epilepsy.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0028-3932
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
37
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
625-36
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| pubmed:dateRevised |
2009-11-11
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| pubmed:meshHeading |
pubmed-meshheading:10390024-Adolescent,
pubmed-meshheading:10390024-Adult,
pubmed-meshheading:10390024-Brain,
pubmed-meshheading:10390024-Case-Control Studies,
pubmed-meshheading:10390024-Dominance, Cerebral,
pubmed-meshheading:10390024-Epilepsy, Temporal Lobe,
pubmed-meshheading:10390024-Factor Analysis, Statistical,
pubmed-meshheading:10390024-Female,
pubmed-meshheading:10390024-Frontal Lobe,
pubmed-meshheading:10390024-Glucose,
pubmed-meshheading:10390024-Humans,
pubmed-meshheading:10390024-Language Disorders,
pubmed-meshheading:10390024-Linear Models,
pubmed-meshheading:10390024-Male,
pubmed-meshheading:10390024-Middle Aged,
pubmed-meshheading:10390024-Multivariate Analysis,
pubmed-meshheading:10390024-Neural Pathways,
pubmed-meshheading:10390024-Temporal Lobe,
pubmed-meshheading:10390024-Thalamus,
pubmed-meshheading:10390024-Tomography, Emission-Computed,
pubmed-meshheading:10390024-Verbal Behavior
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Reorganized cerebral metabolic interactions in temporal lobe epilepsy.
|
| pubmed:affiliation |
Department of Neurology, Heinrich-Heine-University, Duesseldorf, Germany.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|