Linked Life Data

10389628

Source:http://linkedlifedata.com/resource/pubmed/id/10389628

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1999-7-12
pubmed:abstractText
In a significant proportion of cases, anencephaly is associated with thymic enlargement, suggesting a possibility that anencephalic fetuses have a functional disturbance in thymocyte differentiation and development. In this report, we demonstrated that CD99 expression was consistently reduced in cortical thymocytes of all anencephalic fetuses. In addition, the CD99-dependent aggregation of immature cortical thymocytes was almost completely impaired and apoptosis of thymocytes was markedly reduced in several cases. These results are in agreement with previous findings that CD99 regulates the aggregation and apoptosis of various types of cells. These data strongly suggest that functional disturbance of thymocytes and thymic hyperplasia are related to the reduced expression of CD99 molecule in anencephalic fetuses.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0945-6317
pubmed:author
pubmed:issnType
Print
pubmed:volume
434
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
443-9
pubmed:dateRevised
2010-9-1
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Reduced expression of CD99 and functional disturbance in anencephalic cortical thymocytes.
pubmed:affiliation
Department of Pathology, Seoul National University, College of Medicine, Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't