Linked Life Data

10386861

Source:http://linkedlifedata.com/resource/pubmed/id/10386861

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1999-8-11
pubmed:abstractText
An RNA species has been identified whose nucleotide sequence is closely related to the mRNA encoding the murine interferon (IFN)-induced guanylate-binding protein-1 (mGBP1) and an mRNA encoding an isoprenylated protein that is constitutively expressed in various organs in the rat. Sequence analysis of the gene encoding this newly identified RNA reveals that in its 5'-region it is identical to a DNA fragment reported to represent the 5'-region of a gene termed mGBP2. In light of this homology, we term this newly identified gene product mGBP2. mGBP2 is inducible following IFN treatment in animals bearing Gbp1a alleles, in which mGBP1 is transcriptionally upregulated by IFN treatment, as well as in animals bearing Gbp1b alleles, in which mGBP1 is not induced in response to IFN treatment. The genomic organizations of the genes encoding mGBP1 and mGBP2 are similar, and the nucleotide sequences of their IFN-responsive-like elements and their relative locations are conserved. Gbp1 and Gbp2 map to a genetically indistinguishable site on the distal arm of chromosome 3.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1079-9907
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
487-94
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Genomic organization and chromosomal localization of a new member of the murine interferon-induced guanylate-binding protein family.
pubmed:affiliation
Department of Biological Sciences, Fordham University, Bronx, NY 10458, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.