| pubmed-article:10385324 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10385324 | lifeskim:mentions | umls-concept:C0035736 | lld:lifeskim |
| pubmed-article:10385324 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:10385324 | lifeskim:mentions | umls-concept:C0035681 | lld:lifeskim |
| pubmed-article:10385324 | lifeskim:mentions | umls-concept:C0079925 | lld:lifeskim |
| pubmed-article:10385324 | lifeskim:mentions | umls-concept:C0038952 | lld:lifeskim |
| pubmed-article:10385324 | lifeskim:mentions | umls-concept:C2076600 | lld:lifeskim |
| pubmed-article:10385324 | lifeskim:mentions | umls-concept:C1335440 | lld:lifeskim |
| pubmed-article:10385324 | lifeskim:mentions | umls-concept:C0439851 | lld:lifeskim |
| pubmed-article:10385324 | lifeskim:mentions | umls-concept:C1552596 | lld:lifeskim |
| pubmed-article:10385324 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:10385324 | lifeskim:mentions | umls-concept:C1947931 | lld:lifeskim |
| pubmed-article:10385324 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:10385324 | pubmed:dateCreated | 1999-7-15 | lld:pubmed |
| pubmed-article:10385324 | pubmed:abstractText | We have investigated the ability of antisense phosphorothioate oligonucleotides to enhance the survival of mice infected with influenza A virus. The oligonucleotides were complementary to sequences surrounding the translation initiation codons of the viral PB2 or PA genes (PB2-as or PA-as, respectively) of the influenza A virus RNA polymerases. Intravenous administration of PB2-as in a complex with a cationic liposome, Tfx-10, significantly prolonged the mean survival time in days and increased overall survival rates of mice infected with the influenza A virus. Liposomally encapsulated PB2-as inhibited viral growth in lung tissues and reduced pulmonary consolidations. Liposomally encapsulated PB2-as could be an effective therapeutic agent against influenza A virus. | lld:pubmed |
| pubmed-article:10385324 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10385324 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10385324 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10385324 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10385324 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10385324 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10385324 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10385324 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10385324 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10385324 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10385324 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10385324 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10385324 | pubmed:issn | 1087-0156 | lld:pubmed |
| pubmed-article:10385324 | pubmed:author | pubmed-author:AbeTT | lld:pubmed |
| pubmed-article:10385324 | pubmed:author | pubmed-author:FujiwaraMM | lld:pubmed |
| pubmed-article:10385324 | pubmed:author | pubmed-author:YokotaTT | lld:pubmed |
| pubmed-article:10385324 | pubmed:author | pubmed-author:ShigetaSS | lld:pubmed |
| pubmed-article:10385324 | pubmed:author | pubmed-author:HattaTT | lld:pubmed |
| pubmed-article:10385324 | pubmed:author | pubmed-author:MizutaTT | lld:pubmed |
| pubmed-article:10385324 | pubmed:author | pubmed-author:TakakuHH | lld:pubmed |
| pubmed-article:10385324 | pubmed:author | pubmed-author:Miyano-Kurosa... | lld:pubmed |
| pubmed-article:10385324 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10385324 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:10385324 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10385324 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10385324 | pubmed:pagination | 583-7 | lld:pubmed |
| pubmed-article:10385324 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:10385324 | pubmed:meshHeading | pubmed-meshheading:10385324... | lld:pubmed |
| pubmed-article:10385324 | pubmed:meshHeading | pubmed-meshheading:10385324... | lld:pubmed |
| pubmed-article:10385324 | pubmed:meshHeading | pubmed-meshheading:10385324... | lld:pubmed |
| pubmed-article:10385324 | pubmed:meshHeading | pubmed-meshheading:10385324... | lld:pubmed |
| pubmed-article:10385324 | pubmed:meshHeading | pubmed-meshheading:10385324... | lld:pubmed |
| pubmed-article:10385324 | pubmed:meshHeading | pubmed-meshheading:10385324... | lld:pubmed |
| pubmed-article:10385324 | pubmed:meshHeading | pubmed-meshheading:10385324... | lld:pubmed |
| pubmed-article:10385324 | pubmed:meshHeading | pubmed-meshheading:10385324... | lld:pubmed |
| pubmed-article:10385324 | pubmed:meshHeading | pubmed-meshheading:10385324... | lld:pubmed |
| pubmed-article:10385324 | pubmed:meshHeading | pubmed-meshheading:10385324... | lld:pubmed |
| pubmed-article:10385324 | pubmed:meshHeading | pubmed-meshheading:10385324... | lld:pubmed |
| pubmed-article:10385324 | pubmed:meshHeading | pubmed-meshheading:10385324... | lld:pubmed |
| pubmed-article:10385324 | pubmed:meshHeading | pubmed-meshheading:10385324... | lld:pubmed |
| pubmed-article:10385324 | pubmed:meshHeading | pubmed-meshheading:10385324... | lld:pubmed |
| pubmed-article:10385324 | pubmed:meshHeading | pubmed-meshheading:10385324... | lld:pubmed |
| pubmed-article:10385324 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10385324 | pubmed:articleTitle | Antisense oligonucleotides directed against the viral RNA polymerase gene enhance survival of mice infected with influenza A. | lld:pubmed |
| pubmed-article:10385324 | pubmed:affiliation | Rational Drug Design Laboratories, Makutsawa-Machi, Fukushima, Japan. | lld:pubmed |
| pubmed-article:10385324 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10385324 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10385324 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10385324 | lld:pubmed |
