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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1999-10-15
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pubmed:abstractText |
1. Antidromic vasodilatation and plasma extravasation to stimulation of the trigeminal ganglion or its perivascular meningeal fibres was investigated by laser-Doppler flowmetry and 125I-labelled bovin serum albumin in the dura mater and in exteroceptive areas (nasal mucosa, upper eyelid) of anaesthetized rats pretreated with guanethidine and pipecuronium. 2 Trigeminal stimulation at 5 Hz for 20 s elicited unilateral phasic vasodilatation in the dura and lasting response in the nasal mucosa. Resiniferatoxin (1-3 microg kg(-1) i.v.), topical (1%) or systemic capsaicin pretreatment (300 mg kg(-1) s.c. plus 1 mg kg(-1) i.v.) did not inhibit the meningeal responses but abolished or strongly inhibited the nasal responses. Administration of vinpocetine (3 mg kg(-1) i.v.) increased both basal blood flow and the dural vasodilatation to perivascular nerve stimulation. 3. Dural vasodilatation to trigeminal stimulation was not inhibited by the calcitonin gene-related peptide-1 receptor (CGRP-1) antagonist hCGRP8-37 (15 or 50 microg kg(-1) i.v), or the neurokinin-1 receptor antagonist RP 67580 (0.1 mg kg(-1) i.v.) although both antagonists inhibited the nasal response. Neither mucosal nor meningeal responses were inhibited by atropine (5 mg kg(-1) i.v.), hexamethonium (10 mg kg(-1) i.v.) or the vasoactive intestinal polypeptide (VIP) antagonist (p-chloro-D-Phe6-Leul7)VIP (20 microg kg(-1) i.v.). 4. Plasma extravasation in the dura and upper eyelid elicited by electrical stimulation of the trigeminal ganglion was almost completely abolished in rats pretreated with resiniferatoxin (3 microg kg(-1) i.v.). 5. It is concluded that in the rat meningeal vasodilatation evoked by stimulation of trigeminal fibres is mediated by capsaicin-insensitive primary afferents, while plasma extravasation in the dura and upper eyelid and the vasodilatation in the nasal mucosa are mediated by capsaicin-sensitive trigeminal fibres.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10385246-1684734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10385246-1691044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10385246-1717522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10385246-1882089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10385246-2243359,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10385246-2983841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10385246-3288903,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10385246-3401921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10385246-3497587,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10385246-4551675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10385246-6196940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10385246-6199494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10385246-6539108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10385246-6737055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10385246-7477970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10385246-7504417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10385246-7515383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10385246-7536103,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10385246-7606344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10385246-7679023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10385246-7715824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10385246-7716258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10385246-8385759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10385246-8388188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10385246-8538873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10385246-8685245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10385246-8868267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10385246-8911936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10385246-8938261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10385246-9082841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10385246-9151939
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcitonin Gene-Related Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/Capsaicin,
http://linkedlifedata.com/resource/pubmed/chemical/Diterpenes,
http://linkedlifedata.com/resource/pubmed/chemical/Indoles,
http://linkedlifedata.com/resource/pubmed/chemical/Isoindoles,
http://linkedlifedata.com/resource/pubmed/chemical/Neurotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/RP 67580,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Calcitonin Gene-Related...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Neurokinin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Serum Albumin, Radio-Iodinated,
http://linkedlifedata.com/resource/pubmed/chemical/Vasoactive Intestinal Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/calcitonin gene-related peptide...,
http://linkedlifedata.com/resource/pubmed/chemical/resiniferatoxin
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
127
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
457-67
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10385246-Animals,
pubmed-meshheading:10385246-Calcitonin Gene-Related Peptide,
pubmed-meshheading:10385246-Capsaicin,
pubmed-meshheading:10385246-Diterpenes,
pubmed-meshheading:10385246-Electric Stimulation,
pubmed-meshheading:10385246-Indoles,
pubmed-meshheading:10385246-Isoindoles,
pubmed-meshheading:10385246-Laser-Doppler Flowmetry,
pubmed-meshheading:10385246-Male,
pubmed-meshheading:10385246-Meninges,
pubmed-meshheading:10385246-Nasal Mucosa,
pubmed-meshheading:10385246-Nerve Fibers,
pubmed-meshheading:10385246-Neurons, Afferent,
pubmed-meshheading:10385246-Neurotoxins,
pubmed-meshheading:10385246-Peptide Fragments,
pubmed-meshheading:10385246-Rats,
pubmed-meshheading:10385246-Rats, Wistar,
pubmed-meshheading:10385246-Receptors, Calcitonin Gene-Related Peptide,
pubmed-meshheading:10385246-Receptors, Neurokinin-1,
pubmed-meshheading:10385246-Regional Blood Flow,
pubmed-meshheading:10385246-Serum Albumin, Radio-Iodinated,
pubmed-meshheading:10385246-Trigeminal Nerve,
pubmed-meshheading:10385246-Vasoactive Intestinal Peptide,
pubmed-meshheading:10385246-Vasodilation
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pubmed:year |
1999
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pubmed:articleTitle |
Capsaicin-insensitive sensory-efferent meningeal vasodilatation evoked by electrical stimulation of trigeminal nerve fibres in the rat.
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