Linked Life Data

10385141

Source:http://linkedlifedata.com/resource/pubmed/id/10385141

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1999-7-29
pubmed:abstractText
Individuals with different forms of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, carriers of the C677T mutation versus wild type, show differences in enzyme levels; these differences have been hypothesized to be related to DNA methylation and, perhaps, to the nucleotide pool size. Using data from an incident case-control study, we evaluated the combined effect of dietary intake of folate, methionine, vitamin B6, vitamin B12, and alcohol and various forms of the MTHFR gene on risk of colon cancer. Individuals homozygous for the variant form of the MTHFR gene (TT) had a slightly lower risk of colon cancer than did individuals who were wild type [CC, odds ratio (OR) = 0.8, 95% confidence interval (CI) = 0.6-1.1 for men; and OR = 0.9, 95% CI = 0.6-1.2 for women]. High levels of intake of folate, vitamin B6, and vitamin B12 were associated with a 30-40% reduction in risk of colon cancer among those with the TT relative to those with low levels of intake who were CC genotype. Associations were stronger for proximal tumors, in which high levels of intake of these nutrients were associated with a halving of risk among those with the TT genotype. The inverse association with high levels of these nutrients in those with the TT genotype was stronger among those diagnosed at an older age. Although imprecise, the inverse association with the low-risk diet that was high in folate and methionine and without alcohol was observed for both the TT genotype (OR = 0.4 95% CI = 0.1-0.9) and the CC/CT genotype (OR = 0.6, 95% CI = 0.4-1.0), but this association was not seen with the high-risk diet for either the TT or CC/CT genotype. Although associations were generally weak, these findings suggest that those with differing MTHFR genotypes may have different susceptibilities to colon cancer, based on dietary consumption of folate, vitamin B6, and vitamin B12.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1055-9965
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
513-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:10385141-Adult, pubmed-meshheading:10385141-Aged, pubmed-meshheading:10385141-Alcohol Drinking, pubmed-meshheading:10385141-California, pubmed-meshheading:10385141-Case-Control Studies, pubmed-meshheading:10385141-Colonic Neoplasms, pubmed-meshheading:10385141-DNA Methylation, pubmed-meshheading:10385141-Diet, pubmed-meshheading:10385141-Diet Surveys, pubmed-meshheading:10385141-Female, pubmed-meshheading:10385141-Folic Acid, pubmed-meshheading:10385141-Genotype, pubmed-meshheading:10385141-Homozygote, pubmed-meshheading:10385141-Humans, pubmed-meshheading:10385141-Incidence, pubmed-meshheading:10385141-Male, pubmed-meshheading:10385141-Methionine, pubmed-meshheading:10385141-Methylenetetrahydrofolate Reductase (NADPH2), pubmed-meshheading:10385141-Middle Aged, pubmed-meshheading:10385141-Mutation, pubmed-meshheading:10385141-Oxidoreductases Acting on CH-NH Group Donors, pubmed-meshheading:10385141-Pyridoxine, pubmed-meshheading:10385141-Vitamin B 12
pubmed:year
1999
pubmed:articleTitle
Methylenetetrahydrofolate reductase, diet, and risk of colon cancer.
pubmed:affiliation
University of Utah Medical School, Salt Lake City 84108, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't