Source:http://linkedlifedata.com/resource/pubmed/id/10383820
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1999-8-13
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| pubmed:abstractText |
To clarify the role of B cells in the establishment of T cell response against intracellular bacteria, B-cell-deficient (muMT-/-) mice were infected with an intracellular bacteria, Listeria monocytogenes, and T cell response against the bacteria was analyzed. On day 6 of primary Listeria infection, spleen T cells of the muMT-/- mice showed significantly lower levels of proliferative response and IFN-gamma production than those of normal infected mice after in vitro stimulation with listerial antigen. Even in the secondary Listeria infection after immunization with viable bacteria, spleen T cells of the muMT-/- mice proliferated and produced IFN-gamma against listerial antigen at significantly lower levels than those of normal immunized mice. These results demonstrate participation of B cells in priming of Listeria-specific T cells in vivo. However, B cells failed to present Listeria antigen to Listeria-specific T cells in vitro unless Listeria antigen was solubilized. Furthermore, transfer of immune serum from Listeria-infected normal mice failed to enhance the Listeria-specific T cell response of muMT-/- mice. The results indicate that B cells support the T cell response against intracellular bacteria through a mechanism other than their Ig production or antigen presentation function.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD86,
http://linkedlifedata.com/resource/pubmed/chemical/Cd86 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin mu-Chains,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ovalbumin
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
0008-8749
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 1999 Academic Press.
|
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
194
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
178-85
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| pubmed:dateRevised |
2010-11-18
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| pubmed:meshHeading |
pubmed-meshheading:10383820-Animals,
pubmed-meshheading:10383820-Antibodies, Bacterial,
pubmed-meshheading:10383820-Antigen-Presenting Cells,
pubmed-meshheading:10383820-Antigens, CD,
pubmed-meshheading:10383820-Antigens, CD80,
pubmed-meshheading:10383820-Antigens, CD86,
pubmed-meshheading:10383820-B-Lymphocytes,
pubmed-meshheading:10383820-Female,
pubmed-meshheading:10383820-Gene Targeting,
pubmed-meshheading:10383820-Immunization, Passive,
pubmed-meshheading:10383820-Immunoglobulin mu-Chains,
pubmed-meshheading:10383820-Intracellular Fluid,
pubmed-meshheading:10383820-Listeria monocytogenes,
pubmed-meshheading:10383820-Listeriosis,
pubmed-meshheading:10383820-Male,
pubmed-meshheading:10383820-Membrane Glycoproteins,
pubmed-meshheading:10383820-Mice,
pubmed-meshheading:10383820-Mice, Inbred C57BL,
pubmed-meshheading:10383820-Ovalbumin,
pubmed-meshheading:10383820-Solubility,
pubmed-meshheading:10383820-T-Lymphocytes
|
| pubmed:year |
1999
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| pubmed:articleTitle |
The role of B cells in the establishment of T cell response in mice infected with an intracellular bacteria, Listeria monocytogenes.
|
| pubmed:affiliation |
MRC Clinical Sciences Centre, Hammersmith Hospital, London, W12 0NN, United Kingdom. matsuzak@bioreg.kyushu-u.ac.jp
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|