Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
1999-7-19
pubmed:abstractText
Bone morphogenetic proteins (BMPs) comprise a large group of polypeptides in the transforming growth factor beta superfamily with essential physiological functions in morphogenesis and organogenesis in both vertebrates and invertebrates. At present, the role of BMPs in the reproductive system of any species is poorly understood. Here, we have established the existence of a functional BMP system in the ovary, replete with ligand, receptor, and novel cellular functions. In situ hybridization histochemistry identified strong mRNA labeling for BMP-4 and -7 in the theca cells and BMP receptor types IA, IB, and II in the granulosa cells and oocytes of most follicles in ovaries of normal cycling rats. To explore the paracrine function of this BMP system, we examined the effects of recombinant BMP-4 and -7 on FSH (follicle-stimulating hormone)-induced rat granulosa cytodifferentiation in serum-free medium. Both BMP-4 and -7 regulated FSH action in positive and negative ways. Specifically, physiological concentrations of the BMPs enhanced and attenuated the stimulatory action of FSH on estradiol and progesterone production, respectively. These effects were dose- and time-dependent. Furthermore, the BMPs increased granulosa cell sensitivity to FSH. Thus, BMPs have now been identified as molecules that differentially regulate FSH-dependent estradiol and progesterone production in a way that reflects steroidogenesis during the normal estrous cycle. As such, it can be hypothesized that BMPs might be the long-sought "luteinization inhibitor" in Graafian follicles during their growth and development.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/10377406-1167352, http://linkedlifedata.com/resource/pubmed/commentcorrection/10377406-12996444, http://linkedlifedata.com/resource/pubmed/commentcorrection/10377406-1328198, http://linkedlifedata.com/resource/pubmed/commentcorrection/10377406-13821382, http://linkedlifedata.com/resource/pubmed/commentcorrection/10377406-1709938, http://linkedlifedata.com/resource/pubmed/commentcorrection/10377406-1714834, http://linkedlifedata.com/resource/pubmed/commentcorrection/10377406-1715687, http://linkedlifedata.com/resource/pubmed/commentcorrection/10377406-1855461, http://linkedlifedata.com/resource/pubmed/commentcorrection/10377406-227865, http://linkedlifedata.com/resource/pubmed/commentcorrection/10377406-2481605, http://linkedlifedata.com/resource/pubmed/commentcorrection/10377406-2721441, http://linkedlifedata.com/resource/pubmed/commentcorrection/10377406-3061784, http://linkedlifedata.com/resource/pubmed/commentcorrection/10377406-6186541, http://linkedlifedata.com/resource/pubmed/commentcorrection/10377406-744025, http://linkedlifedata.com/resource/pubmed/commentcorrection/10377406-7590254, http://linkedlifedata.com/resource/pubmed/commentcorrection/10377406-7590255, http://linkedlifedata.com/resource/pubmed/commentcorrection/10377406-7705279, http://linkedlifedata.com/resource/pubmed/commentcorrection/10377406-7790373, http://linkedlifedata.com/resource/pubmed/commentcorrection/10377406-7791754, http://linkedlifedata.com/resource/pubmed/commentcorrection/10377406-7945360, http://linkedlifedata.com/resource/pubmed/commentcorrection/10377406-8065329, http://linkedlifedata.com/resource/pubmed/commentcorrection/10377406-8299574, http://linkedlifedata.com/resource/pubmed/commentcorrection/10377406-8373807, http://linkedlifedata.com/resource/pubmed/commentcorrection/10377406-8605043, http://linkedlifedata.com/resource/pubmed/commentcorrection/10377406-8670277, http://linkedlifedata.com/resource/pubmed/commentcorrection/10377406-8674122, http://linkedlifedata.com/resource/pubmed/commentcorrection/10377406-8682290, http://linkedlifedata.com/resource/pubmed/commentcorrection/10377406-8791534, http://linkedlifedata.com/resource/pubmed/commentcorrection/10377406-8923832, http://linkedlifedata.com/resource/pubmed/commentcorrection/10377406-9111068, http://linkedlifedata.com/resource/pubmed/commentcorrection/10377406-9207184, http://linkedlifedata.com/resource/pubmed/commentcorrection/10377406-9393997, http://linkedlifedata.com/resource/pubmed/commentcorrection/10377406-9433969, http://linkedlifedata.com/resource/pubmed/commentcorrection/10377406-9510958, http://linkedlifedata.com/resource/pubmed/commentcorrection/10377406-9577407, http://linkedlifedata.com/resource/pubmed/commentcorrection/10377406-9724040, http://linkedlifedata.com/resource/pubmed/commentcorrection/10377406-9849956
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Bmp4 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Bmp7 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Protein 4, http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Protein 7, http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Protein Receptors, http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Follicle Stimulating Hormone, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Growth Factor, http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
22
pubmed:volume
96
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7282-7
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
A functional bone morphogenetic protein system in the ovary.
pubmed:affiliation
Department of Reproductive Medicine, University of California at San Diego, La Jolla, CA 92093-0633, USA. sshimasaki@ucsd.edu
pubmed:publicationType
Journal Article
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