| pubmed-article:10375506 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10375506 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:10375506 | lifeskim:mentions | umls-concept:C0043342 | lld:lifeskim |
| pubmed-article:10375506 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:10375506 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:10375506 | pubmed:dateCreated | 1999-8-19 | lld:pubmed |
| pubmed-article:10375506 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10375506 | pubmed:abstractText | XTcf-3 is an HMG box transcription factor that mediates Xenopus dorsal-ventral axis formation. As a Wnt pathway effector, XTcf-3 interacts with beta-catenin and activates the expression of the dorsal organizing gene siamois, while in the absence of beta-catenin, XTcf-3 functions as a transcriptional repressor. We show that XTcf-3 contains amino- and carboxy-terminal repressor domains and have identified a Xenopus member of the C-terminal Binding Protein family of transcriptional co-repressors (XCtBP) as the C-terminal co-repressor. We show that two XCtBP binding sites near the XTcf-3 carboxy-terminus are required for the interaction of XTcf-3 and XCtBP and for the transcriptional repression mediated by the XTcf-3 carboxy-terminal domain. By fusing the GAL4 activation domain to XCtBP we have generated an antimorphic protein, XCtBP/G4A, that activates siamois transcription through an interaction with endogenous XTcf-3. Ectopic expression of XCtBP/G4A demonstrates that XCtBP functions in the regulation of head and notochord development. Our data support a role for XCtBP as a co-repressor throughout Xenopus development and indicate that XCtBP/G4A will be a useful tool in determining how XCtBP functions in various developmental processes. | lld:pubmed |
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| pubmed-article:10375506 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10375506 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10375506 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10375506 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10375506 | pubmed:issn | 0950-1991 | lld:pubmed |
| pubmed-article:10375506 | pubmed:author | pubmed-author:BatesRR | lld:pubmed |
| pubmed-article:10375506 | pubmed:author | pubmed-author:BrownJ DJD | lld:pubmed |
| pubmed-article:10375506 | pubmed:author | pubmed-author:BrannonMM | lld:pubmed |
| pubmed-article:10375506 | pubmed:author | pubmed-author:MoonR TRT | lld:pubmed |
| pubmed-article:10375506 | pubmed:author | pubmed-author:KimelmanDD | lld:pubmed |
| pubmed-article:10375506 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10375506 | pubmed:volume | 126 | lld:pubmed |
| pubmed-article:10375506 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10375506 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10375506 | pubmed:pagination | 3159-70 | lld:pubmed |
| pubmed-article:10375506 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:10375506 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10375506 | pubmed:articleTitle | XCtBP is a XTcf-3 co-repressor with roles throughout Xenopus development. | lld:pubmed |
| pubmed-article:10375506 | pubmed:affiliation | Department of Biochemistry, Howard Hughes Medical Institute, Center for Developmental Biology, University of Washington School of Medicine, Seattle, Washington 98195-7350, USA. kimelman@u.washington.edu. | lld:pubmed |
| pubmed-article:10375506 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10375506 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| entrez-gene:398147 | entrezgene:pubmed | pubmed-article:10375506 | lld:entrezgene |
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