Linked Life Data

10366150

Source:http://linkedlifedata.com/resource/pubmed/id/10366150

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1999-6-24
pubmed:abstractText
The cyclin-dependent kinase inhibitor p27KIP1 has been proposed as a valuable prognostic indicator for a variety of human neoplasms. Immunohistochemical reactivity for p27KIP1 and the proliferation marker Ki67/Mib1 were investigated in 90 thyroid carcinomas of follicular cell origin. The neoplasms were divided into three prognostic groups on the basis of their morphologic features: group 1, well-differentiated papillary or follicular carcinomas with favorable pathologic features (43 papillary carcinomas and 4 minimally invasive follicular carcinomas); group 2, papillary or follicular carcinomas with unfavorable pathologic features (21 poorly differentiated carcinomas and 2 papillary carcinomas, tall cell variant); and group 3, undifferentiated, or anaplastic, carcinomas. p27KIP1 expression (p = 0.007) and Ki67/Mib1 labeling index (p = 0.02) showed a strong correlation with the subdivision of the thyroid carcinomas in the three prognostic groups with a significant linear trend for tumors with low p27KIP1 (p = 0.002) and high Ki67/Mib1 labeling index (p = 0.005) to segregate into the unfavorable categories (groups 2 and 3). Low p27KIP1 expression, but not cellular proliferation, was related to adverse prognostic factors, such as large tumor size (p = 0.03) and extrathyroidal extension (p = 0.01), but the correlation was not independent of the subdivision in the three groups. Low p27KIP1 expression (p = 0.03) and high proliferative rate (p = 0.02) were associated with poor survival, reflecting the close association between patient morbidity and mortality rates and tumor differentiation. No significant association could be seen between p27KIP1 or cellular proliferation and clinicopathologic parameters (e.g., age, sex, tumor size, extrathyroidal extension, vascular invasion, lymph node metastases, distant metastases, tumor stage, and survival rate) within any of the groups, or the histologic diagnosis of papillary versus follicular carcinoma irrespective of their degree of differentiation. Modulation of p27KIP1 and cellular proliferation patterns in thyroid carcinoma correlate with tumor differentiation and support the morphologic classification of thyroid carcinoma into prognostically relevant categories.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0147-5185
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
678-85
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:10366150-Adenocarcinoma, Follicular, pubmed-meshheading:10366150-Adult, pubmed-meshheading:10366150-Aged, pubmed-meshheading:10366150-Carcinoma, Papillary, pubmed-meshheading:10366150-Cell Cycle Proteins, pubmed-meshheading:10366150-Cyclin-Dependent Kinase Inhibitor p27, pubmed-meshheading:10366150-Cyclin-Dependent Kinases, pubmed-meshheading:10366150-Disease-Free Survival, pubmed-meshheading:10366150-Down-Regulation, pubmed-meshheading:10366150-Female, pubmed-meshheading:10366150-Humans, pubmed-meshheading:10366150-Immunoenzyme Techniques, pubmed-meshheading:10366150-Ki-67 Antigen, pubmed-meshheading:10366150-Male, pubmed-meshheading:10366150-Microtubule-Associated Proteins, pubmed-meshheading:10366150-Middle Aged, pubmed-meshheading:10366150-Prognosis, pubmed-meshheading:10366150-Thyroid Neoplasms, pubmed-meshheading:10366150-Tumor Suppressor Proteins
pubmed:year
1999
pubmed:articleTitle
Downregulation of p27KIP1 and Ki67/Mib1 labeling index support the classification of thyroid carcinoma into prognostically relevant categories.
pubmed:affiliation
Department of Pathology, Yale University, New Haven, Connecticut 06520-8070, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't