Source:http://linkedlifedata.com/resource/pubmed/id/10360808
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1999-6-16
|
| pubmed:abstractText |
We compared the immune activation profile of 46 HIV-negative and 75 HIV-positive Israelis infected with HIV-1 subtype B, with 85 HIV-negative and 102 HIV-positive Ethiopian immigrants to Israel, who were infected with HIV subtype C. The HIV-negative Ethiopians had exceedingly high blood levels of eosinophils, immunoglobulin E (IgE), and p75s tumor-necrosis factor receptors (p75sTNFR); secretion of interleukin-4 (IL-4) and IL-10 by peripheral blood mononuclear cells (PBMC); proportion of human leukocyte antigen (HLA)-DR+ cells within CD3+, CD4+, and CD8+ T-cell subsets; and proportion of CD45RO+ CD4+ cells; while having significantly lower secretion of interferon-gamma (IFN-gamma) by PBMC and percentage of CD45RA+ CD4+ and CD28+ CD8+ cells. HIV infection in both populations was associated with reduced IL-2, IL-4, IL-10, and IL-12 secretion, number of CD28+ and CD45RA+ CD8+ cells, and increased number of HLA-DR+-CD3+, CD4+, and CD8+ cells, and CD45RO+ CD8+ cells. Thus, infection with HIV-1 subtypes B and C of studied Israelis and Ethiopians, respectively, results in a similar immune activation profile at all stages of the infection when living in the same environment, despite the striking different immune profile observed in the HIV-negative Israeli and Ethiopian populations. Together with our previous observations, this indicates that HIV subtype is not a major determinant in the natural course of HIV infection.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
1525-4135
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
21
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
157-63
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10360808-Antigens, CD,
pubmed-meshheading:10360808-Cross-Sectional Studies,
pubmed-meshheading:10360808-Cytokines,
pubmed-meshheading:10360808-Disease Progression,
pubmed-meshheading:10360808-Eosinophils,
pubmed-meshheading:10360808-Ethiopia,
pubmed-meshheading:10360808-Female,
pubmed-meshheading:10360808-HIV Infections,
pubmed-meshheading:10360808-HIV Seronegativity,
pubmed-meshheading:10360808-HIV-1,
pubmed-meshheading:10360808-Humans,
pubmed-meshheading:10360808-Immunoglobulin E,
pubmed-meshheading:10360808-Israel,
pubmed-meshheading:10360808-Leukocyte Count,
pubmed-meshheading:10360808-Leukocytes, Mononuclear,
pubmed-meshheading:10360808-Lymphocyte Activation,
pubmed-meshheading:10360808-Male,
pubmed-meshheading:10360808-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:10360808-Sexuality,
pubmed-meshheading:10360808-T-Lymphocyte Subsets
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Infection by different HIV-1 subtypes (B and C) results in a similar immune activation profile despite distinct immune backgrounds.
|
| pubmed:affiliation |
R. Ben-Ari Institute of Clinical Immunology, AIDS Center, Kaplan Medical Center, Hebrew University Hadassah Medical School, Rehovot, Israel.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|