Source:http://linkedlifedata.com/resource/pubmed/id/10360173
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1999-6-17
|
| pubmed:abstractText |
The protooncogene c-myc regulates cell growth, differentiation, and apoptosis, and its aberrant expression is frequently observed in human cancer. However, the consequences of activating c-Myc in an adult tissue, in which these cellular processes are part of normal homeostasis, remain unknown. In order to achieve this, we have targeted expression of a switchable form of the c-Myc protein to the skin epidermis, a well characterized homeostatic tissue. We show that activation of c-MycER in adult suprabasal epidermis rapidly triggers proliferation and disrupts differentiation of postmitotic keratinocytes. Sustained activation of c-Myc is sufficient to induce papillomatosis together with angiogenesis--changes that resemble hyperplastic actinic keratosis, a commonly observed human precancerous epithelial lesion. All these premalignant changes spontaneously regress upon deactivation of c-MycER.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
1097-2765
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
3
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
565-77
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:10360173-Animals,
pubmed-meshheading:10360173-Cell Differentiation,
pubmed-meshheading:10360173-Cell Division,
pubmed-meshheading:10360173-Epidermis,
pubmed-meshheading:10360173-Estrogen Antagonists,
pubmed-meshheading:10360173-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:10360173-Hair Follicle,
pubmed-meshheading:10360173-Humans,
pubmed-meshheading:10360173-Hyperplasia,
pubmed-meshheading:10360173-Keratinocytes,
pubmed-meshheading:10360173-Male,
pubmed-meshheading:10360173-Mice,
pubmed-meshheading:10360173-Mice, Inbred C57BL,
pubmed-meshheading:10360173-Mice, Inbred CBA,
pubmed-meshheading:10360173-Mice, Transgenic,
pubmed-meshheading:10360173-Neovascularization, Pathologic,
pubmed-meshheading:10360173-Papilloma,
pubmed-meshheading:10360173-Phenotype,
pubmed-meshheading:10360173-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:10360173-Skin Neoplasms,
pubmed-meshheading:10360173-Tamoxifen
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion.
|
| pubmed:affiliation |
Imperial Cancer Research Fund, London, United Kingdom. s.pelengaris@icrf.icnet.uk
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|