Linked Life Data

10358252

Source:http://linkedlifedata.com/resource/pubmed/id/10358252

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1999-7-1
pubmed:abstractText
This study examined whether the inflammatory mediators interleukin (IL-1beta) and beta-glucuronidase (betaG) are present in the gingival crevicular fluid (GCF) of children undergoing rapid palatal expansion and whether their levels vary upon activation of the appliance and movement of the maxillary first molars. Nine adolescent patients who needed palatal expansion were studied. Each patient received a periodontal prophylaxis and instruction in proper home care, including rinsing with chlorhexidine. Four weeks later, a modified Hyrax appliance was inserted. The jackscrew was activated twice daily until the appropriate expansion was achieved. GCF samples were collected at 2 pretreatment observation periods and 9 observation periods after placement of the appliance. Samples were collected with filter paper strips and analyzed by means of ELISA and time-dependent fluorometry for IL-1beta and betaG, respectively. The values recorded at the observation period 2 weeks after the periodontal prophylaxis were used as baseline. Paired t tests were used to compare mediator levels at this baseline to the levels obtained at each of the subsequent observations. The results indicate that (1) betaG and IL-1beta are present in GCF of young, healthy individuals, (2) their levels decrease following a strict regimen of plaque control, (3) orthodontic/orthopedic forces evoke changes in the levels of the inflammatory mediators IL-1beta and betaG in the periodontal tissues that can be detected in GCF. The results of this study support the hypothesis that mechanical stimulus causes an inflammatory reaction within the periodontal tissues, which in turn may trigger the biological processes associated with bone remodeling.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0889-5406
pubmed:author
pubmed:issnType
Print
pubmed:volume
115
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
686-96
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Interleukin-1beta and beta-glucuronidase in gingival crevicular fluid from molars during rapid palatal expansion.
pubmed:affiliation
Columbia University School of Dental & Oral Surgery, New York, NY, USA.
pubmed:publicationType
Journal Article