Source:http://linkedlifedata.com/resource/pubmed/id/10351956
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
1999-6-29
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| pubmed:abstractText |
A number of chemokines are produced by alveolar cells in the course of inflammatory reactions of sarcoidosis. C-C chemokine receptor 2 (CCR2) is a prominent receptor for the monocyte chemoattractant protein (MCP) group of C-C chemokines. A transition causing a valine to isoleucine substitution in transmembrane domain I of the CCR2 gene (CCR2-64I) that has a protective effect against the progression of human immunodeficiency virus-1 (HIV-1) disease has been described. To elucidate the role of this CCR2 polymorphism in sarcoidosis, we investigated the distribution of the CCR2-64I in 100 subjects with sarcoidosis (40.2 +/- 18.6 yr [mean +/- SD], 37:63 [male:female]) and 122 healthy control subjects (44.4 +/- 14.1 yr, 75:47). The distribution of the CCR2-64I allele was significantly different between subjects with sarcoidosis and healthy control subjects (p < 0.001). The presence of the CCR2-64I allele conferred a lower risk for the development of sarcoidosis (adjusted odds ratio = 0.369, 95% CI = 0.203 to 0.673). Our study suggests that this polymorphism may play a role in the pathogenesis of sarcoidosis, and further studies are needed to define the role of CCR2-64I.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
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| pubmed:issn |
1073-449X
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
159
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
2021-3
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10351956-Adolescent,
pubmed-meshheading:10351956-Adult,
pubmed-meshheading:10351956-Aged,
pubmed-meshheading:10351956-Aged, 80 and over,
pubmed-meshheading:10351956-Alleles,
pubmed-meshheading:10351956-Case-Control Studies,
pubmed-meshheading:10351956-Child,
pubmed-meshheading:10351956-Female,
pubmed-meshheading:10351956-Gene Frequency,
pubmed-meshheading:10351956-Genetic Predisposition to Disease,
pubmed-meshheading:10351956-Humans,
pubmed-meshheading:10351956-Japan,
pubmed-meshheading:10351956-Male,
pubmed-meshheading:10351956-Middle Aged,
pubmed-meshheading:10351956-Odds Ratio,
pubmed-meshheading:10351956-Polymorphism, Genetic,
pubmed-meshheading:10351956-Receptors, CCR2,
pubmed-meshheading:10351956-Receptors, Chemokine,
pubmed-meshheading:10351956-Reference Values,
pubmed-meshheading:10351956-Sarcoidosis,
pubmed-meshheading:10351956-Sex Characteristics
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
The role of the C-C chemokine receptor 2 gene polymorphism V64I (CCR2-64I) in sarcoidosis in a Japanese population.
|
| pubmed:affiliation |
First Department of Medicine, School of Medicine, Hokkaido University, Sapporo, Japan. nhizawa@med.hoki.dai.ac.jp
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|