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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1999-6-29
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pubmed:abstractText |
Chromosome 14q was screened for loci modulating immunoglobulin E (IgE) phenotypes in 15 extended and 45 nuclear asthmatic families using a panel of 14 microsatellite markers. We examined the reported linkage between the TCR A/D locus on 14q11.2 and specific (cognate) allergic responses and observed supportive evidence for linkage between a general skin prick test reactivity trait (but not with total serum IgE) and TCRA microsatellite (in the total sample of informative sib-pairs p = 0.039, in selected sample of one or zero affected parent p = 0.017). We also show suggestive evidence for a novel linkage between markers D14S75 and D14S63 on 14q13-23 and log total serum IgE (p = 0.034 and p = 0.0029). The evidence for linkage with marker D14S63 on 14q23 is strengthened by the finding of association of allele 165 to log IgE (p = 0.0029). We conclude that chromosome 14q may contain a locus close to TCR A/D at 14q11.2 linked to skin prick reactivity and a locus at 14q13- 23 linked to total serum IgE.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1073-449X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
159
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1796-802
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:10351921-Adolescent,
pubmed-meshheading:10351921-Adult,
pubmed-meshheading:10351921-Aged,
pubmed-meshheading:10351921-Aged, 80 and over,
pubmed-meshheading:10351921-Alleles,
pubmed-meshheading:10351921-Allergens,
pubmed-meshheading:10351921-Asthma,
pubmed-meshheading:10351921-Child,
pubmed-meshheading:10351921-Child, Preschool,
pubmed-meshheading:10351921-Chromosome Mapping,
pubmed-meshheading:10351921-Chromosomes, Human, Pair 14,
pubmed-meshheading:10351921-Female,
pubmed-meshheading:10351921-Genetic Linkage,
pubmed-meshheading:10351921-Genetic Markers,
pubmed-meshheading:10351921-Humans,
pubmed-meshheading:10351921-Immunoglobulin E,
pubmed-meshheading:10351921-Male,
pubmed-meshheading:10351921-Middle Aged,
pubmed-meshheading:10351921-Phenotype,
pubmed-meshheading:10351921-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:10351921-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:10351921-Skin Tests
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pubmed:year |
1999
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pubmed:articleTitle |
Suggestive evidence for genetic linkage between IgE phenotypes and chromosome 14q markers.
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pubmed:affiliation |
Molecular Medicine Unit and ICRF, Ashley Wing, St. James's University Hospital, Leeds, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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