pubmed-article:10349617 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:10349617 | lifeskim:mentions | umls-concept:C1522424 | lld:lifeskim |
pubmed-article:10349617 | lifeskim:mentions | umls-concept:C0013936 | lld:lifeskim |
pubmed-article:10349617 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
pubmed-article:10349617 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
pubmed-article:10349617 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
pubmed-article:10349617 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
pubmed-article:10349617 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
pubmed-article:10349617 | lifeskim:mentions | umls-concept:C1334043 | lld:lifeskim |
pubmed-article:10349617 | lifeskim:mentions | umls-concept:C1883220 | lld:lifeskim |
pubmed-article:10349617 | pubmed:issue | 1-2 | lld:pubmed |
pubmed-article:10349617 | pubmed:dateCreated | 1999-7-20 | lld:pubmed |
pubmed-article:10349617 | pubmed:abstractText | The transcription factor FAST-1 has recently been shown to play a key role in the specification of mesoderm by TGF beta superfamily signals in the early Xenopus embryo. We have cloned Fast1, a mouse homologue of Xenopus FAST-1, and characterized its expression during embryogenesis and function in activin/TGF beta signal transduction. In vitro, Fast1 associates with Smads in response to an activin/TGF beta signal to form a complex that recognizes the Xenopus activin responsive element (ARE) targeted by Xenopus FAST-1. In intact cells, introduction of Fast1 confers activin/TGF beta regulation of an ARE-luciferase reporter. In embryos, Fast1 is expressed predominantly throughout the epiblast before gastrulation and declines as development progresses. We propose that mouse Fast1, like Xenopus FAST-1, mediates TGF beta superfamily signals specifying developmental fate during early embryogenesis. | lld:pubmed |
pubmed-article:10349617 | pubmed:language | eng | lld:pubmed |
pubmed-article:10349617 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10349617 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:10349617 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10349617 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10349617 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10349617 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:10349617 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10349617 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10349617 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10349617 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:10349617 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:10349617 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10349617 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10349617 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10349617 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10349617 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10349617 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10349617 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10349617 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10349617 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:10349617 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:10349617 | pubmed:month | Dec | lld:pubmed |
pubmed-article:10349617 | pubmed:issn | 0925-4773 | lld:pubmed |
pubmed-article:10349617 | pubmed:author | pubmed-author:WhitmanMM | lld:pubmed |
pubmed-article:10349617 | pubmed:author | pubmed-author:ChewAA | lld:pubmed |
pubmed-article:10349617 | pubmed:author | pubmed-author:WeisbergEE | lld:pubmed |
pubmed-article:10349617 | pubmed:author | pubmed-author:HoganB LBL | lld:pubmed |
pubmed-article:10349617 | pubmed:author | pubmed-author:FarnsworthC... | lld:pubmed |
pubmed-article:10349617 | pubmed:author | pubmed-author:WinnierG EGE | lld:pubmed |
pubmed-article:10349617 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:10349617 | pubmed:volume | 79 | lld:pubmed |
pubmed-article:10349617 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:10349617 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:10349617 | pubmed:pagination | 17-27 | lld:pubmed |
pubmed-article:10349617 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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pubmed-article:10349617 | pubmed:year | 1998 | lld:pubmed |
pubmed-article:10349617 | pubmed:articleTitle | A mouse homologue of FAST-1 transduces TGF beta superfamily signals and is expressed during early embryogenesis. | lld:pubmed |
pubmed-article:10349617 | pubmed:affiliation | Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. | lld:pubmed |
pubmed-article:10349617 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:10349617 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:10349617 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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