|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1-2
|
|
pubmed:dateCreated |
1999-7-20
|
|
pubmed:abstractText |
The transcription factor FAST-1 has recently been shown to play a key role in the specification of mesoderm by TGF beta superfamily signals in the early Xenopus embryo. We have cloned Fast1, a mouse homologue of Xenopus FAST-1, and characterized its expression during embryogenesis and function in activin/TGF beta signal transduction. In vitro, Fast1 associates with Smads in response to an activin/TGF beta signal to form a complex that recognizes the Xenopus activin responsive element (ARE) targeted by Xenopus FAST-1. In intact cells, introduction of Fast1 confers activin/TGF beta regulation of an ARE-luciferase reporter. In embryos, Fast1 is expressed predominantly throughout the epiblast before gastrulation and declines as development progresses. We propose that mouse Fast1, like Xenopus FAST-1, mediates TGF beta superfamily signals specifying developmental fate during early embryogenesis.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/FOXH1 protein, Xenopus,
http://linkedlifedata.com/resource/pubmed/chemical/FOXH1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Forkhead Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Foxh1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/SMAD2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/SMAD3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/SMAD4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Smad Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Smad2 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Smad2 protein, Xenopus,
http://linkedlifedata.com/resource/pubmed/chemical/Smad2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Smad3 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Smad3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Smad4 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Smad4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/Xenopus Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Xsmad4a protein, Xenopus,
http://linkedlifedata.com/resource/pubmed/chemical/Xsmad4b protein, Xenopus,
http://linkedlifedata.com/resource/pubmed/chemical/madh3 protein, Xenopus
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0925-4773
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
79
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
17-27
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:10349617-Animals,
pubmed-meshheading:10349617-Cloning, Molecular,
pubmed-meshheading:10349617-DNA-Binding Proteins,
pubmed-meshheading:10349617-Forkhead Transcription Factors,
pubmed-meshheading:10349617-Gastrula,
pubmed-meshheading:10349617-Gene Expression Regulation, Developmental,
pubmed-meshheading:10349617-Humans,
pubmed-meshheading:10349617-Mice,
pubmed-meshheading:10349617-Sequence Homology, Amino Acid,
pubmed-meshheading:10349617-Signal Transduction,
pubmed-meshheading:10349617-Smad Proteins,
pubmed-meshheading:10349617-Smad2 Protein,
pubmed-meshheading:10349617-Smad3 Protein,
pubmed-meshheading:10349617-Smad4 Protein,
pubmed-meshheading:10349617-Trans-Activators,
pubmed-meshheading:10349617-Transcription, Genetic,
pubmed-meshheading:10349617-Transcription Factors,
pubmed-meshheading:10349617-Transforming Growth Factor beta,
pubmed-meshheading:10349617-Xenopus,
pubmed-meshheading:10349617-Xenopus Proteins
|
|
pubmed:year |
1998
|
|
pubmed:articleTitle |
A mouse homologue of FAST-1 transduces TGF beta superfamily signals and is expressed during early embryogenesis.
|
|
pubmed:affiliation |
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
