Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1999-6-28
pubmed:abstractText
Salmonella typhi is the only species of Salmonella which grows exclusively in humans, in whom it causes enteric typhoid fever. Strains of S. typhi show very little variation in electrophoretic types, restriction fragment length polymorphisms, cell envelope proteins, and intervening sequences, but the same strains are very heterogeneous for ribotypes which are detected with the restriction endonuclease PstI. In addition, the genome of S. typhi has been proven to undergo genomic rearrangement due to homologous recombination between the seven copies of rrn genes. The relationship between ribotype heterogeneity and genomic rearrangement was investigated. Strains of S. typhi which belong to 23 different genome types were analyzed by ribotyping. A limited number of ribotypes were found within the same genome type group; e. g., most strains of genome type 3 belonged to only two different ribotypes, which result from recombination between rrnH and rrnG operons. Different genome type groups normally have different ribotypes. The size and identity of the PstI fragment containing each of the seven different rrn operons from S. typhi Ty2 were determined, and from these data, one can infer how genomic rearrangement forms new ribotypes. It is postulated that genomic rearrangement, rather than mutation, is largely responsible for producing the ribotype heterogeneity in S. typhi.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/10348867-13084879, http://linkedlifedata.com/resource/pubmed/commentcorrection/10348867-1513268, http://linkedlifedata.com/resource/pubmed/commentcorrection/10348867-1752306, http://linkedlifedata.com/resource/pubmed/commentcorrection/10348867-1916294, http://linkedlifedata.com/resource/pubmed/commentcorrection/10348867-1972158, http://linkedlifedata.com/resource/pubmed/commentcorrection/10348867-1973153, http://linkedlifedata.com/resource/pubmed/commentcorrection/10348867-2087223, http://linkedlifedata.com/resource/pubmed/commentcorrection/10348867-2471748, http://linkedlifedata.com/resource/pubmed/commentcorrection/10348867-2900793, http://linkedlifedata.com/resource/pubmed/commentcorrection/10348867-2915026, http://linkedlifedata.com/resource/pubmed/commentcorrection/10348867-6111554, http://linkedlifedata.com/resource/pubmed/commentcorrection/10348867-6789329, http://linkedlifedata.com/resource/pubmed/commentcorrection/10348867-7592437, http://linkedlifedata.com/resource/pubmed/commentcorrection/10348867-7665489, http://linkedlifedata.com/resource/pubmed/commentcorrection/10348867-7768842, http://linkedlifedata.com/resource/pubmed/commentcorrection/10348867-7862625, http://linkedlifedata.com/resource/pubmed/commentcorrection/10348867-791071, http://linkedlifedata.com/resource/pubmed/commentcorrection/10348867-7928989, http://linkedlifedata.com/resource/pubmed/commentcorrection/10348867-8106312, http://linkedlifedata.com/resource/pubmed/commentcorrection/10348867-8320226, http://linkedlifedata.com/resource/pubmed/commentcorrection/10348867-8752356, http://linkedlifedata.com/resource/pubmed/commentcorrection/10348867-8816795
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0021-9193
pubmed:author
pubmed:issnType
Print
pubmed:volume
181
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3536-41
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Role of genomic rearrangements in producing new ribotypes of Salmonella typhi.
pubmed:affiliation
Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada T2N 1N4.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't