|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0015928,
umls-concept:C0017262,
umls-concept:C0018801,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0919418,
umls-concept:C1152568,
umls-concept:C1332739,
umls-concept:C1511576,
umls-concept:C1707455,
umls-concept:C2911684
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
1999-7-1
|
|
pubmed:abstractText |
Terminal differentiation of cardiac myocyte is associated with their permanent withdrawal from the cell cycle. In adult end-stage heart failure, significant numbers of myocytes express proliferating cell nuclear antigen yet fail to progress to cell division. Cyclin dependent kinase inhibitors are powerful inhibitors of the cell cycle and may play a direct role both in myocyte development and in preventing cell division in the adult.
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|
pubmed:commentsCorrections |
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0195-668X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
20
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
604-11
|
|
pubmed:dateRevised |
2009-11-19
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|
pubmed:meshHeading |
pubmed-meshheading:10337545-Adult,
pubmed-meshheading:10337545-Animals,
pubmed-meshheading:10337545-Biological Markers,
pubmed-meshheading:10337545-Blotting, Western,
pubmed-meshheading:10337545-Cells, Cultured,
pubmed-meshheading:10337545-Cyclin-Dependent Kinases,
pubmed-meshheading:10337545-Embryonic and Fetal Development,
pubmed-meshheading:10337545-Female,
pubmed-meshheading:10337545-Fetus,
pubmed-meshheading:10337545-Heart,
pubmed-meshheading:10337545-Heart Failure,
pubmed-meshheading:10337545-Humans,
pubmed-meshheading:10337545-Male,
pubmed-meshheading:10337545-Myocardium,
pubmed-meshheading:10337545-Rats,
pubmed-meshheading:10337545-Rats, Sprague-Dawley,
pubmed-meshheading:10337545-Retinoblastoma Protein,
pubmed-meshheading:10337545-Sensitivity and Specificity
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|
pubmed:year |
1999
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|
pubmed:articleTitle |
Cyclin-dependent kinase inhibitor expression in human heart failure. A comparison with fetal development.
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|
pubmed:affiliation |
Imperial College of School of Medicine, National Heart and Lung Institute, London, U.K.
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|
pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro,
Research Support, Non-U.S. Gov't
|
