Source:http://linkedlifedata.com/resource/pubmed/id/10331483
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1999-6-7
|
| pubmed:abstractText |
Kawasaki disease (KD) is a systemic vasculitis preferentially affecting coronary arteries. Extensive monocytes/macrophages infiltrate in the vascular lesions, implying the involvement of a chemotactic cytokine in their recruitment. We investigated the role of monocyte chemoattractant protein-1 (MCP-1, also termed monocyte chemotactic and activating factor) in KD. In the immunohistochemical studies using the cardiac tissues of patients with fatal KD, MCP-1 but not interleukin (IL) -8 or macrophage inflammatory protein-1alpha was localized at the extracellular matrix associated with mononuclear cellular infiltration. The sites of MCP-1 expression correlated with the distribution of the acute inflammation, including early coronary vasculitis. In prospectively studied patients with KD, circulating levels of MCP-1, IL-8, tumor necrosis factor alpha (TNF-alpha), and IL-1alpha were elevated in 73, 77, 57, and 0% of samples before gamma globulin (GG) treatment (400 mg/kg x 5 days = total 2 g/kg), respectively, compared with respective control values. GG treatment correlated with a rapid decrease in the circulating levels of MCP-1 (P = 0.001) but not IL-8 (P = 0.19) or TNF-alpha (P = 0.33). In the sensitive Western blotting, MCP-1 bound to GG. Furthermore, GG inhibited the MCP-1-induced Ca2+ influx in a human monocytic cell line in vitro. These findings suggest a role of MCP-1 in KD, and indicate that GG treatment may block MCP-1 activity, thus alleviating KD vasculitis.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL2,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL4,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-8,
http://linkedlifedata.com/resource/pubmed/chemical/Macrophage Inflammatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/gamma-Globulins
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| pubmed:status |
MEDLINE
|
| pubmed:month |
May
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| pubmed:issn |
0741-5400
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
65
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
566-72
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10331483-Blotting, Western,
pubmed-meshheading:10331483-Calcium,
pubmed-meshheading:10331483-Cell Line,
pubmed-meshheading:10331483-Chemokine CCL2,
pubmed-meshheading:10331483-Chemokine CCL4,
pubmed-meshheading:10331483-Child,
pubmed-meshheading:10331483-Child, Preschool,
pubmed-meshheading:10331483-Humans,
pubmed-meshheading:10331483-Immunohistochemistry,
pubmed-meshheading:10331483-Infant,
pubmed-meshheading:10331483-Interleukin-1,
pubmed-meshheading:10331483-Interleukin-8,
pubmed-meshheading:10331483-Macrophage Inflammatory Proteins,
pubmed-meshheading:10331483-Monocytes,
pubmed-meshheading:10331483-Mucocutaneous Lymph Node Syndrome,
pubmed-meshheading:10331483-Myocardium,
pubmed-meshheading:10331483-Tumor Necrosis Factor-alpha,
pubmed-meshheading:10331483-gamma-Globulins
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| pubmed:year |
1999
|
| pubmed:articleTitle |
Dramatic decrease of circulating levels of monocyte chemoattractant protein-1 in Kawasaki disease after gamma globulin treatment.
|
| pubmed:affiliation |
Department of Pediatrics, Chiba University School of Medicine, Chiba-shi, Japan. terai@med.m.chiba-u.ac.jp
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| pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
|