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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1999-7-1
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pubmed:abstractText |
We examined the effects of blockers of N-methyl-D-asparate (NMDA) and +/- -alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)/kainate receptors on the maintenance of self-sustaining status epilepticus (SSSE) induced in rats by brief intermittent electrical stimulation of the perforant path (PPS). Blocking of NMDA receptor at the PCP site by MK-801 (0.5 mg/kg, i.p.) or ketamine (10 mg/kg, i.p.) as well as at the glycine allosteric site by intrahippocampal 5,7-dichlorokynurenic acid (5,7-DCK, 10 nmol), rapidly and irreversibly aborted both behavioral and electrographic manifestation of SSS. Intrahippocampal injection of the AMPA/kainate receptor blocker 6-cyano7-nitroquinixaline-3-dione (CNQX, 10 nmol) transiently suppressed seizures, which reappeared 4-5 h later. We suggest that the maintenance phase of SSSE depends on activation of NMDA receptors and that NMDA receptor blockers may be a promising class of compounds for the treatment of status epilepticus.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/5,7-dichlorokynurenic acid,
http://linkedlifedata.com/resource/pubmed/chemical/6-Cyano-7-nitroquinoxaline-2,3-dione,
http://linkedlifedata.com/resource/pubmed/chemical/Anticonvulsants,
http://linkedlifedata.com/resource/pubmed/chemical/Dizocilpine Maleate,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Ketamine,
http://linkedlifedata.com/resource/pubmed/chemical/Kynurenic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, AMPA,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Kainic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
265
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
187-90
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10327162-6-Cyano-7-nitroquinoxaline-2,3-dione,
pubmed-meshheading:10327162-Action Potentials,
pubmed-meshheading:10327162-Animals,
pubmed-meshheading:10327162-Anticonvulsants,
pubmed-meshheading:10327162-Disease Models, Animal,
pubmed-meshheading:10327162-Dizocilpine Maleate,
pubmed-meshheading:10327162-Electric Stimulation,
pubmed-meshheading:10327162-Excitatory Amino Acid Antagonists,
pubmed-meshheading:10327162-Hippocampus,
pubmed-meshheading:10327162-Ketamine,
pubmed-meshheading:10327162-Kynurenic Acid,
pubmed-meshheading:10327162-Male,
pubmed-meshheading:10327162-Perforant Pathway,
pubmed-meshheading:10327162-Rats,
pubmed-meshheading:10327162-Rats, Wistar,
pubmed-meshheading:10327162-Receptors, AMPA,
pubmed-meshheading:10327162-Receptors, Kainic Acid,
pubmed-meshheading:10327162-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:10327162-Status Epilepticus
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pubmed:year |
1999
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pubmed:articleTitle |
N-methyl-D-asparate receptor antagonists abolish the maintenance phase of self-sustaining status epilepticus in rat.
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pubmed:affiliation |
Department of Neurology and Brain Research Institute, UCLA School of Medicine, Los Angeles, CA, USA. mazarati@ucla.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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