Linked Life Data

1032653

Source:http://linkedlifedata.com/resource/pubmed/id/1032653

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1978-7-24
pubmed:abstractText
The study of Ca+2 and Mg+2 complexes of tetracycline in buffered solution was undertaken to determine their stoichiometry and the chelation sites. Circular dichroism was used to follow complex formation. Modified tetracyclines, in which potential complexation sites were blocked, were used to determine the participation of particular sites in complexation. Calcium formed a 2:1 metal-ion to ligand complex, while the magnesium complex formed at a 1:1 ratio. Formation of the calcium complex involved addition of one metal ion to the C-10, C-11 site with subsequent addition of a second metal ion at the C-12, C-1 site. The magnesium chelate occurred at the C-11, C-12 beta-diketone site.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-3549
pubmed:author
pubmed:issnType
Print
pubmed:volume
65
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1728-32
pubmed:dateRevised
2000-12-18
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
Circular dichroism spectra of tetracycline complexes with Mg+2 and Ca+2.
pubmed:publicationType
Journal Article