Linked Life Data

10320623

Source:http://linkedlifedata.com/resource/pubmed/id/10320623

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1999-7-2
pubmed:abstractText
Two groups of children (6-15 years) from a Schistosoma haematobium endemic area were followed for 9 months after praziquantel treatment. Seventy-three children came from an area of high infection while 67 children came from an area of low infection. Pre-treatment infection prevalence in the high infection area (76.6%) was significantly higher than that in low infection area (36.3%). Levels of anti-SEA immunoglobulin (Ig)A and IgM were significantly higher and levels of IgG3 significantly lower in children from the low infection area. Nine months after treatment, infection prevalence was significantly higher in the high infection area (29.0%) (where re-infection rates were higher) than in the low infection area (12.9%). Children from the high infection area were six times more likely to get re-infected than those from the low infection area, while younger children were 30 times more likely to get re-infected than older children. These results are discussed in relation to differences in transmission and the development of acquired immunity. Pre-treatment levels of IgM and the difference between IgE and IgG4 were positively associated with re-infection in the high infection area. These results are discussed in relation to the interpretation of simple correlations between infection and some antibody levels and the inference of causal relationships between observed epidemiological and immunological patterns.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0141-9838
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
253-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
A comparison of re-infection rates with Schistosoma haematobium following chemotherapy in areas with high and low levels of infection.
pubmed:affiliation
Wellcome Trust Centre for the Epidemiology of Infectious Diseases, Department of Zoology, South Parks Road, University of Oxford, Oxford, OX1 3PS, UK.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't