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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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|
pubmed:dateCreated |
1999-6-8
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pubmed:abstractText |
In previous clinical studies, excellent visualization of tumor lesions has been observed with 131I-labeled monoclonal antibody (mAb) G250 in patients with renal cell carcinoma (RCC). In several cases, 131I-cG250 immunoscintigraphy disclosed tumor lesions that were not visualized by radiography or CT. To improve image quality, we aimed to develop a 99mTc-labeled mAb G250 preparation for radioimmunodetection of RCC. We studied in vitro stability, biodistribution and imaging potential of three 99mTc-labeled G250 preparations in nude mice with subcutaneous RCC xenografts.125I-G250 and the nonspecific mAb 131I-MN14 were used as control antibodies.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0161-5505
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
829-36
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pubmed:dateRevised |
2011-7-29
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pubmed:meshHeading |
pubmed-meshheading:10319758-Animals,
pubmed-meshheading:10319758-Antibodies, Monoclonal,
pubmed-meshheading:10319758-Antineoplastic Agents,
pubmed-meshheading:10319758-Carcinoma, Renal Cell,
pubmed-meshheading:10319758-Chromatography, High Pressure Liquid,
pubmed-meshheading:10319758-Drug Stability,
pubmed-meshheading:10319758-Immunoglobulin G,
pubmed-meshheading:10319758-Isotope Labeling,
pubmed-meshheading:10319758-Kidney Neoplasms,
pubmed-meshheading:10319758-Mice,
pubmed-meshheading:10319758-Mice, Inbred BALB C,
pubmed-meshheading:10319758-Mice, Nude,
pubmed-meshheading:10319758-Neoplasm Transplantation,
pubmed-meshheading:10319758-Organotechnetium Compounds,
pubmed-meshheading:10319758-Radioimmunodetection,
pubmed-meshheading:10319758-Radiopharmaceuticals,
pubmed-meshheading:10319758-Technetium Tc 99m Mertiatide,
pubmed-meshheading:10319758-Tissue Distribution
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pubmed:year |
1999
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pubmed:articleTitle |
In vivo and in vitro characterizations of three 99mTc-labeled monoclonal antibody G250 preparations.
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pubmed:affiliation |
Department of Urology, University Hospital Nijmegen, The Netherlands.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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