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pubmed-article:10231597pubmed:abstractTextChanges in dehydrogenase activity of some continuous cell lines were studied during the response to acute infection in vitro with HIV-1 variants having different biological features. Soon after infection, the dehydrogenase activity of infected cells increased, and this increase was greater and more prolonged with the HIV-1 r/h variant than with the HIV-1 s/l variant. Later stages showed decreased dehydrogenase activity of HIV-1-infected cells compared to the noninfected control; this is a manifestation of the cytodestructive effect of the virus. The changes increased monotonously (but not in direct proportion) with an increase in the infecting dose.lld:pubmed
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pubmed-article:10231597pubmed:articleTitleDehydrogenase activity of infected cells and biological properties of HIV-1 variants.lld:pubmed
pubmed-article:10231597pubmed:affiliationIvanovsky Institute of Virology, Russian Academy of Medical Sciences, Moscow, 123098, Russia.lld:pubmed
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