| pubmed-article:10227978 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10227978 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:10227978 | lifeskim:mentions | umls-concept:C0023516 | lld:lifeskim |
| pubmed-article:10227978 | lifeskim:mentions | umls-concept:C0023884 | lld:lifeskim |
| pubmed-article:10227978 | lifeskim:mentions | umls-concept:C2350466 | lld:lifeskim |
| pubmed-article:10227978 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:10227978 | lifeskim:mentions | umls-concept:C1511545 | lld:lifeskim |
| pubmed-article:10227978 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:10227978 | pubmed:dateCreated | 1999-5-20 | lld:pubmed |
| pubmed-article:10227978 | pubmed:abstractText | In contrast to peripheral lymphoid organs, a high percentage of T cells in the liver are CD4+NKT cells. We asked whether adhesion molecules play any role in the accumulation of CD4+NKT cells in the liver. Liver CD4+NKT cells expressed ICAM-1 and high levels of LFA-1. In the livers of LFA-1-deficient mice, the number of CD4+NKT cells was markedly decreased. This reduction was restricted to the liver, and no reduction was found in the other organs analyzed. In contrast, the number of liver CD4+NKT cells in ICAM-1-deficient mice was only marginally reduced. In a reciprocal radiation thymocyte reconstitution system with LFA-1-deficient and wild-type mice, LFA-1 expressed on liver cells other than CD4+NKT cells was required for an accumulation of CD4+NKT cells in the liver. These results demonstrate a crucial role for LFA-1 in the accumulation of CD4+NKT cells in the liver. | lld:pubmed |
| pubmed-article:10227978 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10227978 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10227978 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:10227978 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10227978 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10227978 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10227978 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10227978 | pubmed:month | May | lld:pubmed |
| pubmed-article:10227978 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:10227978 | pubmed:author | pubmed-author:KaufmannS HSH | lld:pubmed |
| pubmed-article:10227978 | pubmed:author | pubmed-author:MaoT STS | lld:pubmed |
| pubmed-article:10227978 | pubmed:author | pubmed-author:EmotoMM | lld:pubmed |
| pubmed-article:10227978 | pubmed:author | pubmed-author:SchmitsRR | lld:pubmed |
| pubmed-article:10227978 | pubmed:author | pubmed-author:MittrückerH... | lld:pubmed |
| pubmed-article:10227978 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10227978 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10227978 | pubmed:volume | 162 | lld:pubmed |
| pubmed-article:10227978 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10227978 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10227978 | pubmed:pagination | 5094-8 | lld:pubmed |
| pubmed-article:10227978 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:10227978 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10227978 | pubmed:articleTitle | Critical role of leukocyte function-associated antigen-1 in liver accumulation of CD4+NKT cells. | lld:pubmed |
| pubmed-article:10227978 | pubmed:affiliation | Department of Immunology, Max-Planck-Institute for Infection Biology, Berlin, Germany. | lld:pubmed |
| pubmed-article:10227978 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10227978 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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