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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1999-5-20
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pubmed:abstractText |
In contrast to peripheral lymphoid organs, a high percentage of T cells in the liver are CD4+NKT cells. We asked whether adhesion molecules play any role in the accumulation of CD4+NKT cells in the liver. Liver CD4+NKT cells expressed ICAM-1 and high levels of LFA-1. In the livers of LFA-1-deficient mice, the number of CD4+NKT cells was markedly decreased. This reduction was restricted to the liver, and no reduction was found in the other organs analyzed. In contrast, the number of liver CD4+NKT cells in ICAM-1-deficient mice was only marginally reduced. In a reciprocal radiation thymocyte reconstitution system with LFA-1-deficient and wild-type mice, LFA-1 expressed on liver cells other than CD4+NKT cells was required for an accumulation of CD4+NKT cells in the liver. These results demonstrate a crucial role for LFA-1 in the accumulation of CD4+NKT cells in the liver.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
162
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5094-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10227978-Adoptive Transfer,
pubmed-meshheading:10227978-Animals,
pubmed-meshheading:10227978-Antigens,
pubmed-meshheading:10227978-Antigens, Surface,
pubmed-meshheading:10227978-CD4-Positive T-Lymphocytes,
pubmed-meshheading:10227978-Cell Movement,
pubmed-meshheading:10227978-Intercellular Adhesion Molecule-1,
pubmed-meshheading:10227978-Killer Cells, Natural,
pubmed-meshheading:10227978-Lectins, C-Type,
pubmed-meshheading:10227978-Liver,
pubmed-meshheading:10227978-Lymphocyte Function-Associated Antigen-1,
pubmed-meshheading:10227978-Lymphoid Tissue,
pubmed-meshheading:10227978-Mice,
pubmed-meshheading:10227978-Mice, Congenic,
pubmed-meshheading:10227978-Mice, Inbred C57BL,
pubmed-meshheading:10227978-Mice, Mutant Strains,
pubmed-meshheading:10227978-Mice, SCID,
pubmed-meshheading:10227978-NK Cell Lectin-Like Receptor Subfamily B,
pubmed-meshheading:10227978-Protein Biosynthesis,
pubmed-meshheading:10227978-Proteins,
pubmed-meshheading:10227978-Radiation Chimera,
pubmed-meshheading:10227978-T-Lymphocyte Subsets,
pubmed-meshheading:10227978-Thymus Gland
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pubmed:year |
1999
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pubmed:articleTitle |
Critical role of leukocyte function-associated antigen-1 in liver accumulation of CD4+NKT cells.
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pubmed:affiliation |
Department of Immunology, Max-Planck-Institute for Infection Biology, Berlin, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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