Source:http://linkedlifedata.com/resource/pubmed/id/10227460
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1999-5-17
|
| pubmed:abstractText |
To characterize the process of the establishment of complete chimerism after allogeneic peripheral blood stem cell transplantation (allo-PBSCT), we determined the origin of leukocytes in peripheral blood (PB) obtained from 23 patients in the very early period after allo-PBSCT using amplification of mini- or microsatellite regions of genomic DNA. Donor-specific alleles were amplified from the PB obtained at day 8 post-transplant for 19 allo-PBSCT patients. Among the 19 patients, 12 showed only donor-specific alleles (complete chimerism) while 7 did both donor and host-specific alleles (mixed chimerism). Although donor specific alleles were amplified in 10 of 12 patients who received allogeneic bone marrow transplantation (allo-BMT) similarly to allo-PBSCT, all of these ten showed mixed chimerism. When the chimeric state was examined in PB samples obtained serially at 2-3-day intervals post-transplant, host-specific alleles in allo-PBSCT patients were not detectable in the PB much earlier than those in allo-BMT patients. These findings indicate that the appearance of donor-derived cells associated with the disappearance of host-derived cells in the circulation occurs earlier after allo-PBSCT as compared with allo-BMT, leading to the rapid establishment of complete chimerism.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0902-4441
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
62
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
265-70
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| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:10227460-Adolescent,
pubmed-meshheading:10227460-Adult,
pubmed-meshheading:10227460-Bone Marrow Transplantation,
pubmed-meshheading:10227460-Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:10227460-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:10227460-Hematopoietic Stem Cells,
pubmed-meshheading:10227460-Histocompatibility Testing,
pubmed-meshheading:10227460-Humans,
pubmed-meshheading:10227460-Leukemia,
pubmed-meshheading:10227460-Leukocytes,
pubmed-meshheading:10227460-Microsatellite Repeats,
pubmed-meshheading:10227460-Middle Aged,
pubmed-meshheading:10227460-Minisatellite Repeats,
pubmed-meshheading:10227460-Myelodysplastic Syndromes,
pubmed-meshheading:10227460-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:10227460-Recombinant Proteins,
pubmed-meshheading:10227460-Time Factors,
pubmed-meshheading:10227460-Transplantation, Homologous,
pubmed-meshheading:10227460-Transplantation Chimera
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Early establishment of hematopoietic chimerism following allogeneic peripheral blood stem cell transplantation in comparison with allogeneic bone marrow transplantation.
|
| pubmed:affiliation |
Third Department of Medicine, Kanazawa University School of Medicine, Isikawa, Japan. snakao@medkanazawa-u.ac.jp
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|