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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2-4
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pubmed:dateCreated |
1999-6-10
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pubmed:abstractText |
The interaction of immune complexes consisting of allergens and allergen-specific IgE with the high-affinity Fcepsilon receptor represents the key event in the induction of symptoms in type I allergic individuals. Immediate-type symptoms result from the release of biological mediators due to allergen-induced cross-linking of FcepsilonRI receptors on mast cells and basophils, whereas FcepsilonRI-mediated presentation of allergen-IgE complexes may contribute to late-phase symptoms through enhanced T cell activation. The interaction of allergens/allergen-specific IgE/FcepsilonRI represents, therefore, an important target for therapeutic intervention strategies in type I allergy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1018-2438
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
118
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
116-8
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pubmed:dateRevised |
2011-6-21
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pubmed:meshHeading |
pubmed-meshheading:10224355-Allergens,
pubmed-meshheading:10224355-Animals,
pubmed-meshheading:10224355-Antigen-Antibody Reactions,
pubmed-meshheading:10224355-Antigens, Plant,
pubmed-meshheading:10224355-Humans,
pubmed-meshheading:10224355-Hypersensitivity,
pubmed-meshheading:10224355-Immunoglobulin E,
pubmed-meshheading:10224355-Mice,
pubmed-meshheading:10224355-Plant Proteins,
pubmed-meshheading:10224355-Pollen,
pubmed-meshheading:10224355-Receptors, IgE,
pubmed-meshheading:10224355-Recombinant Proteins
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pubmed:articleTitle |
An in vitro model for the allergen-IgE-FcARI interaction.
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pubmed:affiliation |
Institute of General and Experimental Pathology, Division of Hematology, AKH, University Vienna, Austria.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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