Source:http://linkedlifedata.com/resource/pubmed/id/10219637
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1999-7-12
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pubmed:abstractText |
This prospective study was designed to determine the role of antineutrophil cytoplasmic autoantibodies (ANCA) in HIV-infected patients. Immunofluorescence tests (IFT) and enzyme-linked immunosorbent assays (ELISA) were applied to sera of 199 consecutive outpatients. In the IFT 20% were positive. An atypical ANCA pattern was demonstrated in 67% of these, 33% revealed a perinuclear staining (pANCA). Specific ELISA revealed proteinase 3 (n = 2), myeloperoxidase (n = 1), lysozyme (n = 2), lactoferrin (n = 1), cathepsin G (n = 1), and human leukocyte elastase (HLE, n = 6). The target antigen remained unidentified in 26 patients. Perinuclear ANCA-positive patients showed atypical antigens in eight of 13 cases; all six patients with anti-HLE revealed a pANCA pattern. The antigens of atypical ANCA-positive patients remained unidentified in 21 of 26 (81%) cases. No signs of vasculitis were present in the ANCA-positive patients. ANCA are frequently found in the sera of HIV-positive patients. They bind to a variety of antigens. No correlation was found between ANCA positivity and autoimmune or opportunistic diseases.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0300-8126
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
92-6
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:10219637-AIDS-Related Opportunistic Infections,
pubmed-meshheading:10219637-Adult,
pubmed-meshheading:10219637-Antibodies, Antineutrophil Cytoplasmic,
pubmed-meshheading:10219637-Antigens, Viral,
pubmed-meshheading:10219637-Cohort Studies,
pubmed-meshheading:10219637-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:10219637-Epitopes,
pubmed-meshheading:10219637-Female,
pubmed-meshheading:10219637-Fluorescent Antibody Technique, Indirect,
pubmed-meshheading:10219637-HIV Infections,
pubmed-meshheading:10219637-Humans,
pubmed-meshheading:10219637-Male,
pubmed-meshheading:10219637-Prospective Studies,
pubmed-meshheading:10219637-Seroepidemiologic Studies
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pubmed:articleTitle |
Seroprevalence and disease association of antineutrophil cytoplasmic autoantibodies and antigens in HIV infection.
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pubmed:affiliation |
Klinik I für Innere Medizin, Universitätskliniken Köln, Germany.
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pubmed:publicationType |
Journal Article
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