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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1999-4-26
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pubmed:abstractText |
Syndecan-1 binds basic fibroblast growth factor (bFGF), modulates neovascularization, plays a role in epithelial differentiation and is up-regulated by WT1. Malignant mesothelioma of the pleura is one of the most aggressive tumours known and expresses high levels of angiogenic growth factors. This study has analysed syndecan-1 expression in mesothelioma tumours and cell lines by immunohistochemistry and immunoblotting, using anti-syndecan-1 antibody directed against the core protein, and has examined its relation to morphology, bFGF, WT1, and intra-tumoural microvascular density (IMD). Shedding of syndecan-1 in the conditioned medium of mesothelioma cell lines was detected in variable amounts. These studies indicate that (1) there is no correlation of syndecan-1 with either bFGF expression or IMD in mesotheliomas in vivo; (2) syndecan-1 is strongly expressed in the epithelial type of mesothelioma and in the epithelial component of biphasic mesotheliomas and the expression is reduced or lost in sarcomatoid differentiation; together with the finding that (3) syndecan-1 correlates with WT1 immuno-expression, this suggests that syndecan-1 might relate to the differentiation state of mesothelial/mesothelioma cells; and (4) syndecan-1-positive tumours are associated with a longer survival (p = 0.02) than mesotheliomas with no or little syndecan-1 expression, on univariate analysis. These findings therefore indicate that syndecan-1 can be an important prognostic indicator in mesotheliomas and its loss may be important in the epithelial-mesenchymal transformation of mesothelioma cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Fibroblast Growth Factor 2,
http://linkedlifedata.com/resource/pubmed/chemical/Heparan Sulfate Proteoglycans,
http://linkedlifedata.com/resource/pubmed/chemical/Heparitin Sulfate,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proteoglycans,
http://linkedlifedata.com/resource/pubmed/chemical/SDC1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Syndecan-1,
http://linkedlifedata.com/resource/pubmed/chemical/Syndecans,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/WT1 Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/perlecan
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-3417
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
186
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
300-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10211120-Adenocarcinoma,
pubmed-meshheading:10211120-Blotting, Western,
pubmed-meshheading:10211120-Cell Differentiation,
pubmed-meshheading:10211120-Chi-Square Distribution,
pubmed-meshheading:10211120-DNA-Binding Proteins,
pubmed-meshheading:10211120-Epithelium,
pubmed-meshheading:10211120-Fibroblast Growth Factor 2,
pubmed-meshheading:10211120-Heparan Sulfate Proteoglycans,
pubmed-meshheading:10211120-Heparitin Sulfate,
pubmed-meshheading:10211120-Humans,
pubmed-meshheading:10211120-Hyperplasia,
pubmed-meshheading:10211120-Immunohistochemistry,
pubmed-meshheading:10211120-Membrane Glycoproteins,
pubmed-meshheading:10211120-Mesothelioma,
pubmed-meshheading:10211120-Neovascularization, Pathologic,
pubmed-meshheading:10211120-Precipitin Tests,
pubmed-meshheading:10211120-Prognosis,
pubmed-meshheading:10211120-Proteoglycans,
pubmed-meshheading:10211120-Survival Rate,
pubmed-meshheading:10211120-Syndecan-1,
pubmed-meshheading:10211120-Syndecans,
pubmed-meshheading:10211120-Transcription Factors,
pubmed-meshheading:10211120-Tumor Markers, Biological,
pubmed-meshheading:10211120-WT1 Proteins
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pubmed:year |
1998
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pubmed:articleTitle |
Syndecan-1 expression in malignant mesothelioma: correlation with cell differentiation, WT1 expression, and clinical outcome.
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pubmed:affiliation |
Department of Pathology, University of Antwerp (UIA), Belgium.
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pubmed:publicationType |
Journal Article
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