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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1999-5-13
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pubmed:abstractText |
Tumor necrosis factor (TNF-alpha)-induced apoptosis is limited by its coactivation of nuclear factor kappa B (NF-kappaB)-dependent anti-apoptotic genes. Sodium salicylate (NaSal) inhibits NF-kappaB activation by limiting phosphorylation and degradation of its bound inhibitor protein, IkappaB-alpha. We examined whether NaSal enhances TNF-alpha-induced apoptosis in cultured human pancreatic cancer cell lines.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-4804
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 1999 Academic Press.
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
56-61
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:10210643-Adenocarcinoma,
pubmed-meshheading:10210643-Apoptosis,
pubmed-meshheading:10210643-Blotting, Western,
pubmed-meshheading:10210643-Cell Nucleus,
pubmed-meshheading:10210643-DNA Fragmentation,
pubmed-meshheading:10210643-DNA-Binding Proteins,
pubmed-meshheading:10210643-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:10210643-Humans,
pubmed-meshheading:10210643-I-kappa B Proteins,
pubmed-meshheading:10210643-NF-kappa B,
pubmed-meshheading:10210643-Pancreatic Neoplasms,
pubmed-meshheading:10210643-Phosphorylation,
pubmed-meshheading:10210643-Sodium Salicylate,
pubmed-meshheading:10210643-Tumor Cells, Cultured,
pubmed-meshheading:10210643-Tumor Necrosis Factor-alpha
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pubmed:year |
1999
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pubmed:articleTitle |
Salicylates inhibit NF-kappaB activation and enhance TNF-alpha-induced apoptosis in human pancreatic cancer cells.
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pubmed:affiliation |
Department of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.
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pubmed:publicationType |
Journal Article
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