10209159

Source:http://linkedlifedata.com/resource/pubmed/id/10209159

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0007613, umls-concept:C0039194, umls-concept:C0851285
pubmed:issue	2
pubmed:dateCreated	1999-5-26
pubmed:abstractText	During the past several years, the critical role of costimulatory molecules in regulating T cell responses has been demonstrated. Costimulatory molecule CD28 enhances whereas CTLA-4 downmodulates T cell responses. An understanding of the integration of the signals mediated by costimulatory molecules and the T cell receptor at the cellular and molecular levels is just beginning to be achieved.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/CA40041
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8913428
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD28, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD86, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation, http://linkedlifedata.com/resource/pubmed/chemical/CD86 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen, http://linkedlifedata.com/resource/pubmed/chemical/CTLA4 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Cd86 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Ctla4 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Immunoconjugates, http://linkedlifedata.com/resource/pubmed/chemical/Lymphokines, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Receptor-CD3 Complex, Antigen..., http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell, http://linkedlifedata.com/resource/pubmed/chemical/abatacept
pubmed:status	MEDLINE
pubmed:month	Apr
pubmed:issn	0955-0674
pubmed:author	pubmed-author:AllisonJ PJP, pubmed-author:ChambersC ACA
pubmed:issnType	Print
pubmed:volume	11
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	203-10
pubmed:dateRevised	2011-11-17
pubmed:meshHeading	pubmed-meshheading:10209159-Animals, pubmed-meshheading:10209159-Antigen Presentation, pubmed-meshheading:10209159-Antigens, CD, pubmed-meshheading:10209159-Antigens, CD28, pubmed-meshheading:10209159-Antigens, CD80, pubmed-meshheading:10209159-Antigens, CD86, pubmed-meshheading:10209159-Antigens, Differentiation, pubmed-meshheading:10209159-CTLA-4 Antigen, pubmed-meshheading:10209159-Humans, pubmed-meshheading:10209159-Immunoconjugates, pubmed-meshheading:10209159-Lymphocyte Activation, pubmed-meshheading:10209159-Lymphokines, pubmed-meshheading:10209159-Membrane Glycoproteins, pubmed-meshheading:10209159-Mice, pubmed-meshheading:10209159-Models, Immunological, pubmed-meshheading:10209159-Receptor-CD3 Complex, Antigen, T-Cell, pubmed-meshheading:10209159-Receptors, Antigen, T-Cell, pubmed-meshheading:10209159-Signal Transduction, pubmed-meshheading:10209159-T-Lymphocytes
pubmed:year	1999
pubmed:articleTitle	Costimulatory regulation of T cell function.
pubmed:affiliation	Howard Hughes Medical Research Institute, Cancer Research Laboratory, Department of Molecular and Cellular Biology, 415 Life Science Addition, University of California, Berkeley, CA 94720, USA. chambers@socrates.berkeley.edu
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't