Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4 Pt 1
pubmed:dateCreated
1999-6-17
pubmed:abstractText
Polymorphisms in glutathione S-transferase (GSTs) may predispose to colorectal cancer through deficient detoxification of environmental carcinogens, although previous results are conflicting. A study with 178 matched case-control pairs was conducted to determine the effect of the GSTT1 and GSTM1 null genotypes and polymorphisms in GSTP1 on colorectal cancer susceptibility. In a secondary analysis, we examined interactions between genotypes and with the N-acetyltransferase 2 (NAT2) genotype. Heterogeneity by age, sex, site, and stage of cancer was also examined. No effect of any genotype for GSTM1, GSTT1, or GSTP1 on colorectal cancer susceptibility was detected. Secondary end points showed that individuals with both the GSTT1 null and NAT2 slow genotypes combined appeared to be at increased risk of colorectal cancer (odds ratio = 2.33; 95% confidence interval, 1.1-5.0). We conclude that GST polymorphisms alone do not predispose to colorectal cancer in northeast England. We also observed possible effects of the GSTT1 null genotype on the age and stage at presentation, and these, together with the findings of an apparent interaction with NAT2 genotypes, need to be confirmed in further studies.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1055-9965
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
289-92
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:10207630-Adult, pubmed-meshheading:10207630-Aged, pubmed-meshheading:10207630-Base Sequence, pubmed-meshheading:10207630-Case-Control Studies, pubmed-meshheading:10207630-Colorectal Neoplasms, pubmed-meshheading:10207630-Confidence Intervals, pubmed-meshheading:10207630-Disease Susceptibility, pubmed-meshheading:10207630-Female, pubmed-meshheading:10207630-Gene Frequency, pubmed-meshheading:10207630-Genetic Markers, pubmed-meshheading:10207630-Genotype, pubmed-meshheading:10207630-Glutathione S-Transferase pi, pubmed-meshheading:10207630-Glutathione Transferase, pubmed-meshheading:10207630-Humans, pubmed-meshheading:10207630-Isoenzymes, pubmed-meshheading:10207630-Male, pubmed-meshheading:10207630-Middle Aged, pubmed-meshheading:10207630-Molecular Sequence Data, pubmed-meshheading:10207630-Odds Ratio, pubmed-meshheading:10207630-Polymerase Chain Reaction, pubmed-meshheading:10207630-Polymorphism, Genetic, pubmed-meshheading:10207630-Risk Assessment, pubmed-meshheading:10207630-Sensitivity and Specificity
pubmed:year
1999
pubmed:articleTitle
Polymorphisms in GSTP1, GSTM1, and GSTT1 and susceptibility to colorectal cancer.
pubmed:affiliation
Department of Pharmacological Sciences, University of Newcastle upon Tyne, England. m.r.welfare@ncl.ac.uk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't