Linked Life Data

10204774

Source:http://linkedlifedata.com/resource/pubmed/id/10204774

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1999-6-3
pubmed:abstractText
The present study examines the effect of dexamethasone treatment on the intensity of changes in T2-weighted and diffusion-weighted (DW) magnetic resonance images occurring in infant rats during and after cerebral hypoxia-ischemia. The right carotid artery was occluded under isoflurane anesthesia in 7-day-old rats and images were acquired in sedated animals using a Bruker 9.4 T magnetic resonance (MR) system. Imaging changes were markedly different in rats pretreated with dexamethasone phosphate (0.1 mg/kg, i.p.) 24 h before hypoxia than in controls. In control animals, areas of hyperintensity ipsilateral to the occlusion occurred during hypoxia-ischemia in both the DW- and T2-weighted images with some recovery of the changes in early posthypoxia. In contrast, in dexamethasone-treated animals, areas of increased hyperintensity in the MR images did not occur. Thus, dexamethasone treatment prevents MR imaging changes during ischemia, suggesting that the cytotoxic edema associated with energy depletion and/or ionic disturbances during ischemia are also prevented by dexamethasone treatment.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0014-4819
pubmed:author
pubmed:issnType
Print
pubmed:volume
125
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
217-20
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Prevention of both T2- and diffusion-weighted increases in image intensity during cerebral hypoxia-ischemia in infant rats pretreated with dexamethasone.
pubmed:affiliation
Biosystems, Institute for Biodiagnostics, National Research Council of Canada, Winnipeg, Manitoba. tuor@ibd.nrc.ca
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't