|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
1999-6-4
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|
pubmed:abstractText |
Radical C-glycosidation of a 3-methylidene-7-oxabicyclo[2.2.1]heptan-2-one derivative with acetobromomannose gave a alpha-C-mannopyranoside that was converted into alpha-D-ManpCH2(1-->3)-D-GalNAc, a C-disaccharide that inhibits beta-galactosidase from jack bean with IC50 = 9.4 microM and Ki = 7.5 microM (mixed mode of inhibition).
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
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pubmed:day |
8
|
|
pubmed:volume |
9
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
793-6
|
|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10201849-Acetylgalactosamine,
pubmed-meshheading:10201849-Animals,
pubmed-meshheading:10201849-Aspergillus,
pubmed-meshheading:10201849-Chickens,
pubmed-meshheading:10201849-Enzyme Inhibitors,
pubmed-meshheading:10201849-Fabaceae,
pubmed-meshheading:10201849-Liver,
pubmed-meshheading:10201849-Mannose,
pubmed-meshheading:10201849-Plants, Medicinal,
pubmed-meshheading:10201849-Rhizopus,
pubmed-meshheading:10201849-beta-Galactosidase
|
|
pubmed:year |
1999
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|
pubmed:articleTitle |
Synthesis of alpha-C(1-->3)-mannopyranoside of N-acetylgalactosamine, a new beta-galactosidase inhibitor.
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|
pubmed:affiliation |
Institut de chimie organique de l'Université de Lausanne, BCH, Lausanne-Dorigny, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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