Linked Life Data

10196374

Source:http://linkedlifedata.com/resource/pubmed/id/10196374

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1999-6-23
pubmed:databankReference
pubmed:abstractText
In analysis of a conserved region of proximal mouse chromosome 7 and human chromosome 19q, we have isolated a novel mouse gene, Zim1 (imprinted zinc-finger gene 1), encoding a typical Kruppel-type (C2H2) zinc-finger protein, located within 30 kb of a known imprinted gene, Peg3 (paternally expressed gene 3). Our studies demonstrate that Zim1 is also imprinted; the gene is expressed mainly from the maternal allele and at high levels only during embryonic and neonatal stages. In contrast to most tissues, Zim1 is expressed biallelically in neonatal and adult brain with slightly more input from the maternal allele. Zim1 produces multiple transcripts that range in size from 7.5 to 15 kb. The 7.5 kb transcript is expressed at highest levels and appears to be embryo specific. Whole mount in situ hybridization analysis indicates that Zim1 is expressed at significant levels in the apical ectodermal ridge of the limb buds during embryogenesis, suggesting a potential role of Zim1 in limb formation. We have identified the potential human ortholog of Zim1 near PEG3 in a conserved, gene-rich region of human chromosome 19q13.4. The close juxtaposition of reciprocally imprinted genes has also been seen in other imprinted regions, such as human 11p15.5/Mmu7 ( H19 / Igf2 ) and suggests that the two genes may be co-regulated. These and other data suggest the presence of an unexplored, conserved imprinted domain in human chromosome 19q13.4 and proximal Mmu7.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0964-6906
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
847-54
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:10196374-Amino Acid Sequence, pubmed-meshheading:10196374-Animals, pubmed-meshheading:10196374-Carrier Proteins, pubmed-meshheading:10196374-Chromosome Mapping, pubmed-meshheading:10196374-Chromosomes, Human, Pair 19, pubmed-meshheading:10196374-Cloning, Molecular, pubmed-meshheading:10196374-DNA-Binding Proteins, pubmed-meshheading:10196374-Embryonic and Fetal Development, pubmed-meshheading:10196374-Female, pubmed-meshheading:10196374-Gene Expression Regulation, Developmental, pubmed-meshheading:10196374-Genomic Imprinting, pubmed-meshheading:10196374-Humans, pubmed-meshheading:10196374-Kruppel-Like Transcription Factors, pubmed-meshheading:10196374-Male, pubmed-meshheading:10196374-Mice, pubmed-meshheading:10196374-Mice, Inbred Strains, pubmed-meshheading:10196374-Molecular Sequence Data, pubmed-meshheading:10196374-Nerve Tissue Proteins, pubmed-meshheading:10196374-Physical Chromosome Mapping, pubmed-meshheading:10196374-Protein Kinases, pubmed-meshheading:10196374-Proteins, pubmed-meshheading:10196374-Repressor Proteins, pubmed-meshheading:10196374-Transcription Factors, pubmed-meshheading:10196374-Zinc Fingers
pubmed:year
1999
pubmed:articleTitle
Zim1, a maternally expressed mouse Kruppel-type zinc-finger gene located in proximal chromosome 7.
pubmed:affiliation
Human Genome Center, Biology and Biotechnology Research Program, L-452, Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA 94551, USA. kim16@llnl.gov
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.