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pubmed-article:10195457pubmed:abstractTextRadio-labeled somatostatin analogs have recently gained popularity as agents useful in intraoperative tumor localization, external scintigraphy and in situ radiotherapy. We have synthesized and characterized a series of novel N-terminally extended multiply-tyrosinated somatostatin analogs that possess high binding affinity for somatostatin receptors, exhibit biological activity comparable to the native peptide and retain these characteristics after iodination. These analogs can be radio-iodinated to high specific activities. Following radioiodination, these analogs exhibit minimal radiolysis and may be clinically useful for tumor localization, scanning and therapy.lld:pubmed
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pubmed-article:10195457pubmed:dateRevised2004-11-17lld:pubmed
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pubmed-article:10195457pubmed:articleTitleSynthesis and characterization of multiply-tyrosinated, multiply-iodinated somatostatin analogs.lld:pubmed
pubmed-article:10195457pubmed:affiliationLouisiana State University University Medical Center, Department of Surgery, Stanley S. Scott Cancer Center, New Orleans 70012-2822, USA. ewolte@lsumc.dulld:pubmed
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