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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1999-5-25
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pubmed:abstractText |
Radio-labeled somatostatin analogs have recently gained popularity as agents useful in intraoperative tumor localization, external scintigraphy and in situ radiotherapy. We have synthesized and characterized a series of novel N-terminally extended multiply-tyrosinated somatostatin analogs that possess high binding affinity for somatostatin receptors, exhibit biological activity comparable to the native peptide and retain these characteristics after iodination. These analogs can be radio-iodinated to high specific activities. Following radioiodination, these analogs exhibit minimal radiolysis and may be clinically useful for tumor localization, scanning and therapy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1397-002X
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pubmed:author |
pubmed-author:CheaII,
pubmed-author:CoyD HDH,
pubmed-author:DiacoD SDS,
pubmed-author:DrouantG JGJ,
pubmed-author:EspenanG DGD,
pubmed-author:FisherD RDR,
pubmed-author:FuselierJ AJA,
pubmed-author:MaloneyT MTM,
pubmed-author:MurphyW AWA,
pubmed-author:NelsonJ AJA,
pubmed-author:O'DorisioM SMS,
pubmed-author:O'DorisioT MTM,
pubmed-author:SharmaCC,
pubmed-author:WolteringE AEA
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pubmed:issnType |
Print
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
201-13
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:10195457-Adenocarcinoma, Bronchiolo-Alveolar,
pubmed-meshheading:10195457-Adenylate Cyclase,
pubmed-meshheading:10195457-Aged,
pubmed-meshheading:10195457-Amino Acid Sequence,
pubmed-meshheading:10195457-Brain Neoplasms,
pubmed-meshheading:10195457-Diagnostic Imaging,
pubmed-meshheading:10195457-Growth Hormone,
pubmed-meshheading:10195457-Humans,
pubmed-meshheading:10195457-Iodine,
pubmed-meshheading:10195457-Lung Neoplasms,
pubmed-meshheading:10195457-Male,
pubmed-meshheading:10195457-Neuroblastoma,
pubmed-meshheading:10195457-Peptides,
pubmed-meshheading:10195457-Radionuclide Imaging,
pubmed-meshheading:10195457-Somatostatin,
pubmed-meshheading:10195457-Tissue Distribution,
pubmed-meshheading:10195457-Tumor Cells, Cultured,
pubmed-meshheading:10195457-Tyrosine
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pubmed:year |
1999
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pubmed:articleTitle |
Synthesis and characterization of multiply-tyrosinated, multiply-iodinated somatostatin analogs.
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pubmed:affiliation |
Louisiana State University University Medical Center, Department of Surgery, Stanley S. Scott Cancer Center, New Orleans 70012-2822, USA. ewolte@lsumc.du
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pubmed:publicationType |
Journal Article,
Clinical Trial
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