Source:http://linkedlifedata.com/resource/pubmed/id/10188762
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1999-6-21
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pubmed:abstractText |
Lamifiban is an intravenously administered, selective, reversible, nonpeptide glycoprotein IIb/IIIa receptor antagonist which inhibits platelet aggregation and thrombus formation by preventing the binding of fibrinogen to platelets. In trials in patients with non-Q wave myocardial infarction (MI) or unstable angina pectoris (PARAGON A and the Canadian Lamifiban Study), the incidence of clinical events at 30 days in patients receiving lamifiban (1 to 5 microg/min) was not significantly different from that in patients receiving aspirin plus heparin or aspirin alone. In PARAGON A, the incidence of clinical events at 6 months was significantly lower after lamifiban (with or without heparin) and aspirin therapy than after standard heparin and aspirin therapy. A large phase III trial (PARAGON B) is under way comparing lamifiban plus aspirin and heparin with standard aspirin and heparin therapy in patients with non-Q wave MI or unstable angina pectoris. In clinical trials, the most common adverse events associated with lamifiban were bleeding complications which were increased by the concomitant administration of heparin.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0012-6667
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
57
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
215-21; discussion 222-3
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:10188762-Acetates,
pubmed-meshheading:10188762-Animals,
pubmed-meshheading:10188762-Bleeding Time,
pubmed-meshheading:10188762-Clinical Trials as Topic,
pubmed-meshheading:10188762-Humans,
pubmed-meshheading:10188762-Platelet Aggregation Inhibitors,
pubmed-meshheading:10188762-Tyrosine
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pubmed:year |
1999
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pubmed:articleTitle |
Lamifiban.
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pubmed:affiliation |
Adis International Limited, Auckland, Mairangi Bay, New Zealand. demail@adis.co.nz
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pubmed:publicationType |
Journal Article,
Review
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