Linked Life Data

10100862

Source:http://linkedlifedata.com/resource/pubmed/id/10100862

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
1999-4-20
pubmed:databankReference
pubmed:abstractText
The surface expression in Staphylococcus carnosus of three different fibronectin binding domains (FNBDs), derived from fibronectin binding proteins of Streptococcus dysgalactiae and Staphylococcus aureus, has been investigated. Surface localization of the chimeric proteins containing the FNBDs was demonstrated. All three surface-displayed FNBDs were demonstrated to bind fibronectin in whole-cell enzyme-linked binding assays. Furthermore, for one of the constructs, intranasal immunizations with the recombinant bacteria resulted in improved antibody responses to a model immunogen present within the chimeric surface proteins. The implications of the results for the design of live bacterial vaccine delivery systems are discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0014-5793
pubmed:author
pubmed:issnType
Print
pubmed:day
12
pubmed:volume
446
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
299-304
pubmed:dateRevised
2010-10-19
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Surface display of functional fibronectin-binding domains on Staphylococcus carnosus.
pubmed:affiliation
Department of Biotechnology, Royal Institute of Technology (KTH), Stockholm, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't