Linked Life Data

10098753

Source:http://linkedlifedata.com/resource/pubmed/id/10098753

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7-8
pubmed:dateCreated
1999-4-13
pubmed:abstractText
Although the mechanisms of action of the transmembrane superfamilies, motility-related protein-1 (MRP-1/CD9) and KAI1/CD82, are not well known, they are reported to suppress the metastasis of several kinds of cancers. The suppression of cell motility by MRP-1/CD9 may cause suppression of the metastasis. As we could not find any reports concerning the expression of MRP-1/CD9 and KAI1/CD82 in oesophageal cancers we investigated their expression in oesophageal specimens. We conducted immunohistochemical staining for MRP1/CD9 against 108 cases of oesophageal squamous cell carcinoma using anti-MRP-1/CD9 monoclonal antibody M31-15, and for KAI1/CD82 against 104 cases using anti-KAI1/CD82 monoclonal antibody C33. To investigate the gradual expression of MRP-1/CD9 and KAI1/CD82, 24 oesophageal dysplasias were immunohistochemically stained using the same method and then investigated. The expression of both MRP-1/CD9 and KAI1/CD82 were positive on the cell membranes of normal oesophageal epithelial cells, but reduced or negative in the cancer cells. Reduced MRP-1/CD9 expressions significantly correlated to tumour depth (P = 0.0009). We found a significantly greater number of reduced or negative expression of MRP-1/CD9 and KAI1/CD82 in lymph node metastatic cases (P = 0.0003 and P= 0.0129, respectively), but not in distant metastatic cases. The 5-year survival rate of MRP-1/CD9-negative and reduced patients was significantly worse than those of positive patients (n = 108, curative cases, RO). Few cases remained KAI1/CD82-positive (9.6%; 10/104) in oesophageal cancer. Twenty (83.3%) and twenty-two (91.7%) cases out of 24 dysplasias were defined as KAI1/CD82-positive and MRP1/CD9-positive, respectively. The decrease in MRP-1/CD9 and KAI1/CD82 expression may facilitate lymph node metastasis in oesophageal squamous cell carcinomas. Knowing the status of the expression of MRP-1/CD9 appears helpful in predicting the prognosis for each patient.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/10098753-1720807, http://linkedlifedata.com/resource/pubmed/commentcorrection/10098753-1840589, http://linkedlifedata.com/resource/pubmed/commentcorrection/10098753-2455569, http://linkedlifedata.com/resource/pubmed/commentcorrection/10098753-7664290, http://linkedlifedata.com/resource/pubmed/commentcorrection/10098753-7754374, http://linkedlifedata.com/resource/pubmed/commentcorrection/10098753-7790364, http://linkedlifedata.com/resource/pubmed/commentcorrection/10098753-7876316, http://linkedlifedata.com/resource/pubmed/commentcorrection/10098753-8478605, http://linkedlifedata.com/resource/pubmed/commentcorrection/10098753-8521390, http://linkedlifedata.com/resource/pubmed/commentcorrection/10098753-8620488, http://linkedlifedata.com/resource/pubmed/commentcorrection/10098753-8813131, http://linkedlifedata.com/resource/pubmed/commentcorrection/10098753-8909232, http://linkedlifedata.com/resource/pubmed/commentcorrection/10098753-9205061
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0007-0920
pubmed:author
pubmed:issnType
Print
pubmed:volume
79
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1168-73
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Motility-related protein (MRP-1/CD9) and KAI1/CD82 expression inversely correlate with lymph node metastasis in oesophageal squamous cell carcinoma.
pubmed:affiliation
Department of Surgery and Surgical Basic Science, Graduate School of Medicine, Kyoto University, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't