Linked Life Data

10098467

Source:http://linkedlifedata.com/resource/pubmed/id/10098467

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pubmed-article:10098467pubmed:abstractTextWe have studied the effect of aging on brain glutathione redox ratio, on brain mitochondrial DNA damage and on motor co-ordination in mice and the possible protective role of late onset administration of sulphur-containing antioxidants. Glutathione redox ratios change to a more oxidized state in whole brain with aging but the changes are much more pronounced when this ratio is measured in brain mitochondria. The levels of 8-oxo-7,8-dihydro-2 '-deoxyguanosine in mitochondrial DNA are much higher in the brain of old animals than in those of young ones. Late onset oral administration of sulphur-containing antioxidants partially prevents oxidation of mitochondrial glutathione and DNA. There is an inverse relationship between age-associated oxidative damage to mitochondrial DNA and motor co-ordination in old mice.lld:pubmed
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pubmed-article:10098467pubmed:articleTitleLate onset administration of oral antioxidants prevents age-related loss of motor co-ordination and brain mitochondrial DNA damage.lld:pubmed
pubmed-article:10098467pubmed:affiliationDepartamento de Fisiología, Facultad de Medicina, Universitat de Valencia, Spain.lld:pubmed
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