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rdf:type |
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lifeskim:mentions |
umls-concept:C0001554,
umls-concept:C0003402,
umls-concept:C0006104,
umls-concept:C0012860,
umls-concept:C0012929,
umls-concept:C0205087,
umls-concept:C0332162,
umls-concept:C0442027,
umls-concept:C1292733,
umls-concept:C1513492,
umls-concept:C1517945,
umls-concept:C1705994
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pubmed:issue |
6
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pubmed:dateCreated |
1999-5-21
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pubmed:abstractText |
We have studied the effect of aging on brain glutathione redox ratio, on brain mitochondrial DNA damage and on motor co-ordination in mice and the possible protective role of late onset administration of sulphur-containing antioxidants. Glutathione redox ratios change to a more oxidized state in whole brain with aging but the changes are much more pronounced when this ratio is measured in brain mitochondria. The levels of 8-oxo-7,8-dihydro-2 '-deoxyguanosine in mitochondrial DNA are much higher in the brain of old animals than in those of young ones. Late onset oral administration of sulphur-containing antioxidants partially prevents oxidation of mitochondrial glutathione and DNA. There is an inverse relationship between age-associated oxidative damage to mitochondrial DNA and motor co-ordination in old mice.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1071-5762
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
617-23
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10098467-Administration, Oral,
pubmed-meshheading:10098467-Aging,
pubmed-meshheading:10098467-Alanine,
pubmed-meshheading:10098467-Animals,
pubmed-meshheading:10098467-Antioxidants,
pubmed-meshheading:10098467-Brain,
pubmed-meshheading:10098467-DNA, Mitochondrial,
pubmed-meshheading:10098467-DNA Damage,
pubmed-meshheading:10098467-Deoxyguanosine,
pubmed-meshheading:10098467-Drug Administration Schedule,
pubmed-meshheading:10098467-Glutathione,
pubmed-meshheading:10098467-Male,
pubmed-meshheading:10098467-Mice,
pubmed-meshheading:10098467-Mice, Inbred Strains,
pubmed-meshheading:10098467-Motor Activity,
pubmed-meshheading:10098467-Oxidation-Reduction,
pubmed-meshheading:10098467-Postural Balance,
pubmed-meshheading:10098467-Sulfur,
pubmed-meshheading:10098467-Thiazoles
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pubmed:year |
1998
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pubmed:articleTitle |
Late onset administration of oral antioxidants prevents age-related loss of motor co-ordination and brain mitochondrial DNA damage.
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pubmed:affiliation |
Departamento de Fisiología, Facultad de Medicina, Universitat de Valencia, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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