Source:http://linkedlifedata.com/resource/pubmed/id/10096245
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1999-4-1
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pubmed:abstractText |
Cyclin-D1 (CD1) expression was analyzed in human mammary carcinomas by immunohistochemical (IHC) and flow-cytometry (FCM) methods: 52.5% and 50% of cases were strong expressors of CD1 by IHC and FCM analysis respectively. The percentage of CD1-positive cells was especially high in node-negative (N-) estrogen-receptor-positive (ER+) tumors, probably as a consequence of CD1 induction by estrogens in steroid-responsive tissues. However, CD1 expression was not related to ER positivity in node-positive tumors (N+). An interesting relationship between CD1 expression and H3-thymidine labelling index (H3Td-LI) was also found: CD1 and H3Td-LI were unrelated in N- tumors, while high CD1 expression was observed in N+ tumors with high DNA synthesis, as assessed by H3Td-LI. The combined measurement of DNA and CD1 showed that 27 specimens were aneuploid, 19 of them (19/27; 70%) strongly expressing CD1. Further studies are needed to clarify the role of CD1 in DNA abnormality of breast tumors. However, we cannot exclude that the CD1 may be differently de-regulated in the last phase of tumor progression, and that CD1 over-expression may contribute to the aneuploidy of mammary carcinomas.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0020-7136
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
84
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
139-44
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pubmed:dateRevised |
2007-7-24
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pubmed:meshHeading |
pubmed-meshheading:10096245-Breast Neoplasms,
pubmed-meshheading:10096245-Carcinoma, Ductal, Breast,
pubmed-meshheading:10096245-Cell Division,
pubmed-meshheading:10096245-Cyclin D1,
pubmed-meshheading:10096245-Female,
pubmed-meshheading:10096245-Flow Cytometry,
pubmed-meshheading:10096245-Humans,
pubmed-meshheading:10096245-Immunohistochemistry,
pubmed-meshheading:10096245-Lymphatic Metastasis,
pubmed-meshheading:10096245-Middle Aged,
pubmed-meshheading:10096245-Neoplasm Proteins,
pubmed-meshheading:10096245-Ploidies,
pubmed-meshheading:10096245-Receptors, Estrogen
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pubmed:year |
1999
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pubmed:articleTitle |
Cyclin-D1 expression in node-positive (N+) and node-negative (N-) infiltrating human mammary carcinomas.
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pubmed:affiliation |
Department of Oncology, University of Pisa, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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