rdf:type |
|
lifeskim:mentions |
umls-concept:C0013470,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0034693,
umls-concept:C0086597,
umls-concept:C0332307,
umls-concept:C0392747,
umls-concept:C0443172,
umls-concept:C0542299,
umls-concept:C0849912,
umls-concept:C1413709
|
pubmed:issue |
1-2
|
pubmed:dateCreated |
1999-5-7
|
pubmed:abstractText |
We investigated whether corticotropin-releasing factor (CRF) receptor type 1 (CRFR1) is involved in emotional stress-induced inhibition of food intake and behavioral changes in rats. The inhibition of food intake and increase in locomotor activity induced by emotional stress using a communication box were reversed by both intracerebroventricular injection of alpha-helical CRF (9-41), a non-selective CRF receptor antagonist, and intraperitoneal injection of a selective non-peptidic CRFR1 antagonist. These results suggest that CRFR1 mediates at least in part the emotional stress-induced inhibition of feeding behavior and increase in locomotor activity.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
0006-8993
|
pubmed:author |
|
pubmed:copyrightInfo |
Copyright 1999 Elsevier Science B.V.
|
pubmed:issnType |
Print
|
pubmed:day |
27
|
pubmed:volume |
823
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
221-5
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:10095032-Animals,
pubmed-meshheading:10095032-Behavior, Animal,
pubmed-meshheading:10095032-Corticotropin-Releasing Hormone,
pubmed-meshheading:10095032-Eating,
pubmed-meshheading:10095032-Electroshock,
pubmed-meshheading:10095032-Hormone Antagonists,
pubmed-meshheading:10095032-Injections, Intraperitoneal,
pubmed-meshheading:10095032-Injections, Intraventricular,
pubmed-meshheading:10095032-Male,
pubmed-meshheading:10095032-Motor Activity,
pubmed-meshheading:10095032-Peptide Fragments,
pubmed-meshheading:10095032-Pyridines,
pubmed-meshheading:10095032-Pyrimidines,
pubmed-meshheading:10095032-Rats,
pubmed-meshheading:10095032-Rats, Wistar,
pubmed-meshheading:10095032-Receptors, Corticotropin-Releasing Hormone,
pubmed-meshheading:10095032-Stress, Psychological
|
pubmed:year |
1999
|
pubmed:articleTitle |
Corticotropin-releasing factor receptor type 1 mediates emotional stress-induced inhibition of food intake and behavioral changes in rats.
|
pubmed:affiliation |
Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women's Medical University, School of Medicine, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.bzi00174@niftyserve.or.jp
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|