10091677

Source:http://linkedlifedata.com/resource/pubmed/id/10091677

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0014442, umls-concept:C0016850, umls-concept:C0243077
pubmed:issue	3
pubmed:dateCreated	1999-5-24
pubmed:abstractText	The synthesis and in vitro activity of a series of substituted furans as a novel structural class of PDE4 inhibitors is described. Comparison of emetic threshold with known PDE4 inhibitors is presented.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/3',5'-Cyclic-AMP Phosphodiesterases, http://linkedlifedata.com/resource/pubmed/chemical/Cyclic Nucleotide..., http://linkedlifedata.com/resource/pubmed/chemical/Furans, http://linkedlifedata.com/resource/pubmed/chemical/Phosphodiesterase Inhibitors
pubmed:status	MEDLINE
pubmed:month	Feb
pubmed:issn	0960-894X
pubmed:author	pubmed-author:BaylyCC, pubmed-author:GirardYY, pubmed-author:HuangZZ, pubmed-author:LalibertéFF, pubmed-author:MacdonaldDD, pubmed-author:PerrierHH, pubmed-author:RasoriRR, pubmed-author:RobichaudAA
pubmed:issnType	Print
pubmed:day	8
pubmed:volume	9
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	323-6
pubmed:dateRevised	2007-11-15
pubmed:meshHeading	pubmed-meshheading:10091677-3',5'-Cyclic-AMP Phosphodiesterases, pubmed-meshheading:10091677-Animals, pubmed-meshheading:10091677-Cyclic Nucleotide Phosphodiesterases, Type 4, pubmed-meshheading:10091677-Ferrets, pubmed-meshheading:10091677-Furans, pubmed-meshheading:10091677-Phosphodiesterase Inhibitors, pubmed-meshheading:10091677-Structure-Activity Relationship, pubmed-meshheading:10091677-Vomiting
pubmed:year	1999
pubmed:articleTitle	Substituted furans as inhibitors of the PDE4 enzyme.
pubmed:affiliation	Merck Frosst Centre for Therapeutic Research, Pointe Claire-Dorval, Québec, Canada.
pubmed:publicationType	Journal Article