Linked Life Data

10091219

Source:http://linkedlifedata.com/resource/pubmed/id/10091219

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1999-6-3
pubmed:abstractText
The effect of nitrendipine on desensitization of beta-adrenoceptors induced by isoprenaline was investigated using rat lungs. Rats were treated with saline, isoprenaline, nitrendipine, or nitrendipine + isoprenaline. After 7 days of treatment, tracheas were isolated and the dissociation constant (Kb) for the propranolol-beta-receptor complex was determined. Lung parenchymal tissue was used to study the binding characteristics of beta-adrenoceptors. The Kb value for the propranolol-beta-receptor complex was found to be up to 6.4-fold higher in trachea isolated from isoprenaline-treated rats (32 +/- 5.4 nM) than from control rats (4.9 +/- 1.2 nM); the Kb value for trachea from isoprenaline + nitrendipine-treated rats was 7.0 +/- 1.2 nM. A 31% reduction in the number of beta-adrenoceptors as compared to those of the control group was observed in the isoprenaline-treated group while the number of the beta-adrenoceptors in the isoprenaline + nitrendipine-treated group was significantly increased as compared to that of the isoprenaline-treated group.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0379-0355
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
833-40
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
In vivo induced desensitization of beta-adrenoceptors in rat lung. Effect of nitrendipine.
pubmed:affiliation
Institute of Physiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
pubmed:publicationType
Journal Article, Comparative Study